Compressed multiwall carbon nanotube composite electrodes provide enhanced electroanalytical performance for determination of serotonin
Compressed multiwall carbon nanotube composite electrodes provide enhanced electroanalytical performance for determination of serotonin
复制标题
DOI：
10.1016/j.electacta.2014.06.050
复制
发表时间：
2014-08-20
影响因子：
6.6
通讯作者：
Patel, Bhavik Anil
中科院分区：
文献类型：
--
作者：
Fagan-Murphy, Aidan;Patel, Bhavik Anil
5-羟色胺（5-HT）是一种重要的神经化学物质，在肠道内存在高浓度。迄今为止，碳纤维和掺硼金刚石电极已广泛用于监测5-HT，但这些电极容易结结，并且难以在某些尺寸和几何形状下制造。碳纳米管已经显示出作为5-HT电分析监测的合适材料的潜力，但是很难操纵成合适的形式。复合电极的制造是一种可以将导电材料塑造成适合生物环境的实用电极几何形状的方法。本工作研究了多壁碳纳米管（MWCNTs）环氧复合电极的压缩如何影响其电分析性能。与非压缩复合电极相比，高度压缩复合电极的电化学性能有显著改善，同时内部和电荷转移电阻降低，可重复性好，批次间可变性也有所改善。压缩MWCNT环氧树脂复合电极，通过优先去除压缩过程中的环氧树脂并增加最终电极的电化学活性表面，导致对铁氰化钾、六胺钌和多巴胺的电流响应增加。对于血清素的检测，与非压缩电极相比，压缩电极具有较低的检测极限和提高的灵敏度。在10 μ M血清素中进行了污垢研究，其中MWCNT压缩电极显示比未压缩电极更不容易污垢。这项工作表明，MWCNT碳环氧树脂的压缩可以产生一种高导电性的材料，这种材料可以被塑造成各种几何形状，从而为电分析测量提供了范围，并为各种系统生产了各种分析设备。(C) 2014 Elsevier Ltd.版权所有。
Serotonin (5-HT) is an important neurochemical that is present in high concentrations within the intestinal tract. Carbon fibre and boron-doped diamond based electrodes have been widely used to date for monitoring 5-HT, however these electrodes are prone to fouling and are difficult to fabricate in certain sizes and geometries. Carbon nanotubes have shown potential as a suitable material for electroanalytical monitoring of 5-HT but can be difficult to manipulate into a suitable form. The fabrication of composite electrodes is an approach that can shape conductive materials into practical electrode geometries suitable for biological environments. This work investigated how compression of multiwall carbon nanotubes (MWCNTs) epoxy composite electrodes can influence their electroanalytical performance. Highly compressed composite electrodes displayed significant improvements in their electrochemical properties along with decreased internal and charge transfer resistance, reproducible behaviour and improved batch to batch variability when compared to non-compressed composite electrodes. Compression of MWCNT epoxy composite electrodes resulted in an increased current response for potassium ferricyanide, ruthenium hexaammine and dopamine, by preferentially removing the epoxy during compression and increasing the electrochemical active surface of the final electrode. For the detection of serotonin, compressed electrodes have a lower limit of detection and improved sensitivity compared to non-compressed electrodes. Fouling studies were carried out in 10 mu M serotonin where the MWCNT compressed electrodes were shown to be less prone to fouling than non-compressed electrodes. This work indicates that the compression of MWCNT carbon-epoxy can result in a highly conductive material that can be moulded to various geometries, thus providing scope for electroanalytical measurements and the production of a wide range of analytical devices for a variety of systems. (C) 2014 Elsevier Ltd. All rights reserved.