Increased release of interleukin-12p40 in MS - Association with intracerebral inflammation
Increased release of interleukin-12p40 in MS - Association with intracerebral inflammation
复制标题
DOI：
10.1212/wnl.51.3.753
复制
发表时间：
1998-09-01
期刊：
影响因子：
9.9
通讯作者：
Hennerici, M
中科院分区：
文献类型：
--
作者：
Fassbender, K;Ragoschke, A;Hennerici, M
目的：白细胞介素（IL）-12的p40亚基最近被证明在MS的活动性病变。我们测试是否IL-12的p40亚基也可以检测到CSF和血清中的这种疾病的患者，如果是这样，是否释放与炎症性疾病的活动。结果如下：这项研究表明，MS中p40亚基而不是异源二聚体p70的区室化释放增加（高达1,000倍）。IL-12 p40的释放与CNS炎症的经典标志物（CSF细胞计数，免疫球蛋白G指数）相关，并且在MRI上具有钆增强斑块的患者中显著增加。此外，IL-12 p40的释放与CSF中髓鞘碱性蛋白的水平相关，髓鞘碱性蛋白作为髓鞘降解的量度。结论：这些结果表明IL-12 p40在MS的病理生理学中的作用。
Objective: The p40 subunit of interleukin (IL)-12 was recently demonstrated in active lesions in MS. We tested whether the p40 subunit of IL-12 can also be detected in CSF and serum of patients with this disease and, if so, whether release is associated with inflammatory disease activity. Results: This study demonstrates an increased (up to 1,000-fold) compartmentalized release of the p40 subunit but not of the heterodimer p70 in MS. Release of IL-12p40 correlated with classic markers of CNS inflammation (CSF cell counts, immunoglobulin G index) and was significantly increased in patients with gadolinium-enhancing plaques on MRI. Moreover, release of IL-12p40 was associated with CSF levels of myelin basic protein as a measure of myelin degradation, Conclusion: These results suggest a role of IL-12p40 in the pathophysiology of MS.