Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
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DOI：
10.1016/j.ejphar.2010.10.059
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发表时间：
2011-01-15
影响因子：
5
通讯作者：
Gault, Victor A.
中科院分区：
文献类型：
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作者：
Porter, David W.;Irwin, Nigel;Gault, Victor A.
酶抗性葡萄糖依赖性促胰岛素多肽 (GIP) 激动剂为 2 型糖尿病治疗提供了治疗潜力。此外，有新的证据表明 GIP 在调节大脑功能方面发挥着直接作用。本研究比较了饮食调整和/或每天两次注射稳定 GIP 激动剂 (d-Ala(2))GIP 对高脂肪喂养小鼠的代谢控制、认知功能和海马突触可塑性的影响。年轻的瑞士小鼠被维持高脂肪饮食 155 天，此时一半的动物转为标准维持饮食。随后给小鼠注射(d-Ala(2))GIP（25 nmol/kg体重；bid.）或盐水载体28天。饮食干预和 (d-Ala(2))GIP 治疗在恢复非空腹血糖控制方面同样有效 (P
Enzyme-resistant glucose-dependent insulinotropic polypeptide (GIP) agonists offer therapeutic potential for type 2 diabetes treatment In addition, there is emerging evidence suggesting that GIP plays a direct role in modulating aspects of brain function. This study compared effects of dietary modification and/or twice-daily injection of the stable GIP agonist, (d-Ala(2))GIP, on metabolic control, cognitive function and hippocampal synaptic plasticity in high-fat fed mice. Young Swiss mice were maintained on high-fat diet for 155 days, at which point half of the animals were switched to standard maintenance diet. Mice were subsequently injected with (d-Ala(2))GIP (25 nmol/kg bodyweight; bid.) or saline vehicle for 28 days. Both dietary intervention and (d-Ala(2))GIP treatment were equally effective in restoring non-fasting glycaemic control (P