Ultrasound Imaging Findings of Acute Testicular Infection in Patients With Coronavirus Disease 2019 A Single-Center-Based Study in Wuhan, China
Ultrasound Imaging Findings of Acute Testicular Infection in Patients With Coronavirus Disease 2019 A Single-Center-Based Study in Wuhan, China
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DOI：
10.1002/jum.15558
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发表时间：
2020-11-11
影响因子：
2.3
通讯作者：
Guo, Ruiqiang
中科院分区：
文献类型：
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作者：
Chen, Liao;Huang, Xin;Guo, Ruiqiang
目的2019冠状病毒病（COVID-19）是由新型严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）引起的全球性流行病，引起了广泛的公共卫生问题。我们的团队在武汉治疗了住院的COVID-19患者，那里是爆发的第一个开始，我们怀疑SARS-CoV-2可能会导致男性患者的睾丸感染。方法我们招募确诊为COVID-19的男性患者，并对阴囊进行床旁超声（US）检查，重点关注急性炎症的发现，如睾丸、附睾或两者的图尼卡白蛋白增厚、肿大和不均匀回声，脓肿，阴囊壁水肿和鞘膜积液。结果共纳入142例COVID-19患者，32例（22.5%）患者在阴囊超声成像中根据诊断标准表现为急性睾丸炎、附睾炎或附睾-睾丸炎。观察到的急性阴囊感染的风险随着年龄的增长而增加，80岁以上男性的发病率达到53.3%。我们还观察到，与非严重COVID-19组相比，严重COVID-19组男性发生附睾-睾丸炎的可能性显著更高（P =. 037）。结论本研究显示了SARS-CoV-2可能导致睾丸或附睾感染的US影像学证据，其风险值得临床医生关注。
Objectives Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic, raising widespread public health concerns. Our team treated hospitalized patients with COVID-19 in Wuhan, where the outbreak first began, and we suspected that SARS-CoV-2 may cause testicular infection in male patients. We conducted this study to explore that observation.Methods We enrolled male patients with a confirmed diagnosis of COVID-19 and performed a bedside ultrasound (US) examination of the scrotum, focused on findings of acute inflammation such as tunica albuginea thickening, enlargement and heterogeneous echogenicity of the testis, epididymis, or both, an abscess, scrotal wall edema, and hydrocele. Then we compared the proportions of observed epididymo-orchitis in patients from different age groups and COVID-19 severity groups.Results A total of 142 patients with COVID-19 were enrolled in our study, and 32 (22.5%) patients had acute orchitis, epididymitis, or epididymo-orchitis on scrotal US imaging, according to the diagnosis criteria. The observed risk of acute scrotal infection increased with age, with the incidence reaching 53.3% in men older than 80 years. We also observed that men with severe COVID-19 had a significantly higher possibility of epididymo-orchitis compared to the nonsevere COVID-19 group (P = .037).Conclusions This study shows US imaging evidence that SARS-CoV-2 may cause infection of the testis or epididymis, and the risk is worthy of the attention of clinicians.