HLA-A, -B, -DRB1 allele and haplotype frequencies in 510 Koreans
HLA-A, -B, -DRB1 allele and haplotype frequencies in 510 Koreans
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DOI：
10.1034/j.1399-0039.1999.530412.x
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发表时间：
1999-04-01
期刊：
影响因子：
--
通讯作者：
Kang, SJ
中科院分区：
文献类型：
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作者：
Park, MH;Kim, HS;Kang, SJ
采用血清学方法（A、B）和聚合酶链反应（PCR）单链构象多态性方法（DRB 1），研究了510名健康无关韩国人的HLA-A、B和DRB 1等位基因和A-B-DRB 1单倍型的频率。共检测到35种DRB 1等位基因，频率最高的是DRB 1 *1302（10.9%）、*0901（9.5%）、*1501（8.2%）、*0803（7.3%）、*0405（73.0%），*0101（6.4%）、*0406（6.0%）和 *0701（6.0%）。HLA-DR 4和DR 14两组多态性最高，每组由8个DRB 1等位基因组成。A-B-DRB 1单倍型有16种，其中A33-B41-DRB 1 *1302为最常见的5种单倍型A33-B58-DRB 1 *1302（3.7%）、A33-B44-DRB 1 *0701（2.9%）、A24-B7-DRB 1 *0101（2.2%）和A24-B52-DRB 1 *1502（2.0%）。东亚人群A-B-DRB 1单倍型分布比较显示，韩国人与日本人最接近，但多态性程度高于日本人。
The frequencies of HLA-A, B, and DRB1 alleles and A-B-DRB1 haplotypes were studied in 510 healthy unrelated Koreans, using serological (for A, B) and polymerase chain reaction (PCR) single strand conformation polymorphism (for DRB1) methods. A total of 35 DRB1 alleles were detected and the most frequent alleles were DRB1*1302 (10.9%), *0901 (9.5%), *1501 (8.2%), *0803 (7.3%), *0405 (73.%), *0101 (6.4%), *0406 (6.0%), and *0701 (6.0%). HLA-DR4 and DR14 groups were most polymorphic, each group composed of eight DRB1 alleles Two-locus associations between HLA-DRB1 and B loci were analyzed. There were 16 A-B-DRB1 haplotypes occurring at frequencies of greater than or equal to 1%, and the five most common haplotypes were A33-B41-DRB1*1302 (5.4%), A33-B58-DRB1*1302 (3.7%), A33-B44-DRB1*0701 (2.9%), A24-B7-DRB1*0101 (2.2%), and A24-B52-DRB1*1502 (2.0%). Comparison of the distribution of A-B-DRB1 haplotypes among East Asian populations revealed that Koreans are closest to Japanese, out show a higher degree of polymorphism compared with Japanese.