Short-chain dehydrogenase/reductase (SDR) relationships:: A large family with eight clusters common to human, animal, and plant genomes
Short-chain dehydrogenase/reductase (SDR) relationships:: A large family with eight clusters common to human, animal, and plant genomes
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DOI：
10.1110/ps.26902
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发表时间：
2002-03-01
期刊：
影响因子：
8
通讯作者：
Persson, B
中科院分区：
文献类型：
--
作者：
Kallberg, Y;Oppermann, U;Persson, B
基因组表征的进展为酶家族的研究开辟了新的途径。人类基因组的可用性使我们能够描绘短链脱氢酶/还原酶（SDR）成员的大家族。虽然人类基因组尚未最终公布，但我们已经发现了63个成员。我们还比较了这些SDR形式与三个模式生物：秀丽隐杆线虫，果蝇，拟南芥。我们在跨基因组比较中检测到八个SDR直系同源簇。其中四个集群代表了扩展的SDR形式，这是在所有生命形式中发现的一个亚组。其他四种是经典的SDR，其活性涉及细胞分化和信号传导。我们还发现了18个SDR基因，它们只存在于所研究的四个基因组中的人类基因组中，反映了哺乳动物特有的酶形式。近一半的这些基因产物代表类固醇脱氢酶，强调这些酶的调节重要性。
The progress in genome characterizations has opened new routes for studying enzyme families. The availability of the human genome enabled us to delineate the large family of short-chain dehydrogenase/reductase (SDR) members. Although the human genome releases are not yet final, we have already found 63 members. We have also compared these SDR forms with those of three model organisms: Caenorhabditis elegans, Drosophila melanogaster, and Arabidopsis thaliana. We detect eight SDR ortholog clusters in a cross-genome comparison. Four of these clusters represent extended SDR forms, a subgroup found in all life forms. The other four are classical SDRs with activities involved in cellular differentiation and signalling. We also find 18 SDR genes that are present only in the human genome of the four genomes studied, reflecting enzyme forms specific to mammals. Close to half of these gene products represent steroid dehydrogenases, emphasizing the regulatory importance of these enzymes.