Immune Recognition of Pathogen-Derived Glycolipids Through Mincle
Immune Recognition of Pathogen-Derived Glycolipids Through Mincle
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DOI：
10.1007/978-981-15-1580-4_2
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发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Yamasaki，Sho
中科院分区：
文献类型：
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作者：
Miyake，Yasunobu;Yamasaki，Sho
Mincle（macrophageinducibleC-typelectin，Clec 4 e，Clecsf 9）最初于1999年被鉴定为C型凝集素受体家族的成员。2008年又报道了Mincle通过与白色念珠菌结合来控制抗真菌免疫的功能。大约在同一时间，据报道Mincle识别受损细胞并通过与ITAM-衔接分子FcRγ偶联诱导无菌炎症。在接下来的一年中，一项突破性的发现报道了Mincle是分枝杆菌索因子（海藻糖-6，6 ′-二霉菌酸酯，TDM）的必需受体。明克尔在这一关键发现后立即引起了越来越多的关注。虽然我们对分枝杆菌的认识已经有了很大的进展，但也发现Mincle与分枝杆菌以外的病原体相互作用。此外，最近还鉴定了Mincle的内源性配体。因此，Mincle现在被认为是自身和非自身配体的危险受体，即所谓的损伤相关分子模式（DAMP）和病原体相关分子模式（PAMP）。本章将概述多任务危险受体Mincle从发现到最新发现所积累的知识。
Mincle (macrophageinducibleC-typelectin, Clec4e, Clecsf9) was originally identified as a member of the C-type lectin receptor family in 1999. Then, the function of Mincle to control antifungal immunity by binding toCandida albicanswas reported in 2008. Around the same time, it was reported that Mincle recognized damaged cells and induced sterile inflammation by coupling with the ITAM-adaptor molecule FcRγ. In the following year, a breakthrough discovery reported that Mincle was an essential receptor for mycobacterial cord factor (trehalose-6,6′-dimycolate, TDM). Mincle gained increasing attention immediately after this critical finding. Although our understanding of the recognition ofMycobacteriahas been advanced significantly, it was also revealed that Mincle interacts with pathogens other thanMycobacteria. In addition, endogenous ligands of Mincle were identified recently. Therefore, Mincle is now considered a danger receptor both for self and non-self ligands, so-called damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). This chapter will give an overview of the accumulated knowledge of the multi-task danger receptor Mincle from its discovery to the latest findings.