Multipotent neurospheres can be derived from forebrain subependymal zone and spinal cord of adult mice after protracted postmortem intervals.
Multipotent neurospheres can be derived from forebrain subependymal zone and spinal cord of adult mice after protracted postmortem intervals.
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经过长时间的尸检后，多能神经球可以源自成年小鼠的前脑室管膜下区和脊髓。
DOI：
10.1006/exnr.1999.7029
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Steindler,DA
中科院分区：
文献类型：
--
作者：
Laywell,ED;Kukekov,VG;Steindler,DA
The adult mammalian CNS harbors a population of multipotent stem/progenitor cells that can be induced to grow as proliferative neurospheresin vitro.We demonstrate here that neurosphere-generating cells can be isolated from adult mouse spinal cord and forebrain subependymal zone after postmortem intervals of up to 140 h, when kept at 4°C, and up to 30 h when kept at room temperature. Although there was an inverse relationship between postmortem interval and the number of neurospheres generated, neurospheres derived under these conditions were proliferative and could give rise to both neurons and glia.
