The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine
The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine
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DOI：
10.1038/sj.tpj.6500382
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发表时间：
2006-09-01
影响因子：
2.8
通讯作者：
Someya, T.
中科院分区：
文献类型：
--
作者：
Sugai, T.;Suzuki, Y.;Someya, T.
我们研究了日本精神病患者5-羟色胺3A和3B受体（HTR 3A和HTR 3B）基因多态性对帕罗西汀引起的恶心的影响。在用相同日剂量的帕罗西汀治疗至少2周后，从78个个体收集血液样品。患者每2周就诊一次，根据临床症状改变帕罗西汀剂量。每次访视时评估恶心。HTR 3B基因Tyr 129 Ser多态性对恶心的发生率有显著影响（P = 0.038）。Logistic回归分析还显示，Tyr/Tyr基因型患者发生恶心的风险是Ser等位基因患者的3.95倍（P = 0.048）。HTR 3A基因多态性和CYP 2D 6基因多态性对恶心的发生率无显著影响。通过Bonferroni检验校正恶心严重程度的平均评分。HTR 3B基因多态性是帕罗西汀引起恶心的重要预测因子。
We investigated the effect of 5-hydroxytryptamine 3A and 3B receptor (HTR3A and HTR3B) gene polymorphisms on nausea induced by paroxetine in Japanese psychiatric patients. Blood samples were collected from 78 individuals after at least 2 weeks treatment with the same daily dose of paroxetine. The patients visited every 2 weeks and the paroxetine dose was changed in response to their clinical symptoms. Nausea was assessed at each visit. The Tyr129Ser polymorphism of the HTR3B gene had a significant effect on the incidence of nausea (P = 0.038). Logistic regression analysis also showed that patients with the Tyr/Tyr genotype had a 3.95-fold (P = 0.048) higher risk of developing nausea than patients with the Ser allele. HTR3A gene polymorphisms and the CYP2D6 gene polymorphisms had no significant effect on the incidence of nausea. The mean score of nausea severity was corrected by the Bonferroni test. HTR3B gene polymorphisms are significant predictors of paroxetine-induced nausea.