Medical history, body size, and cigarette smoking in relation to fatal prostate cancer
Medical history, body size, and cigarette smoking in relation to fatal prostate cancer
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DOI：
10.1007/s10552-009-9441-9
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发表时间：
2010-01-01
影响因子：
2.3
通讯作者：
Weiss, Noel S.
中科院分区：
文献类型：
--
作者：
Weinmann, Sheila;Shapiro, Jean A.;Weiss, Noel S.
前列腺癌有几个已知的危险因素。作为在四个健康维护组织中进行的基于人群的病例对照研究的一部分，作者研究了致命性前列腺癌与几种医学和行为特征之间的关系。病例是1997-2001年期间死于前列腺癌的768名健康计划成员。我们从健康计划成员中随机选择对照组（929），并将其与健康计划，年龄，种族和健康计划成员模式的病例进行匹配。我们检查了首次怀疑前列腺癌前10年的病历，以获得潜在危险因素的信息;匹配的对照组使用相同的参考日期，病例组和对照组的人体测量特征以及良性前列腺肥大、经尿道前列腺切除术、癌症、糖尿病、前列腺炎、高血压和输精管结扎术的个人病史基本相似。根据参考日期前最近的吸烟记录，死于前列腺癌的男性比对照组更可能是吸烟者（比值比1.5，95%置信区间1.1-2.0）。观察到的与最近吸烟相关的风险增加与其他几项研究的结果一致。然而，与一些报告相反，我们观察到致命的前列腺癌与一些先前的健康状况或身体大小的测量之间没有联系。
Prostate cancer has few known risk factors. As part of a population-based case-control study conducted in four health maintenance organizations, the authors examined the associations between fatal prostate cancer and several medical and behavioral characteristics.Cases were 768 health plan members who died of prostate adenocarcinoma during the period 1997-2001. We randomly selected controls (929) from the health plan membership and matched them to cases on health plan, age, race, and pattern of health plan membership. We examined medical records to obtain information on potential risk factors during the 10 years before the date on which prostate cancer was first suspected; the same reference date was used for the matched controls.Anthropometric characteristics, as well as personal histories of benign prostatic hypertrophy, transurethral prostatectomy, cancer, diabetes, prostatitis, hypertension, and vasectomy were largely similar for cases and controls. Men who died from prostate cancer were more likely than controls to have been cigarette smokers according to the most recent smoking notation before the reference date (odds ratio 1.5, 95% confidence interval 1.1-2.0).The observed increase in risk associated with recent cigarette smoking is consistent with the findings of several other studies. However, in contrast with some reports, we observed no connection between fatal prostate cancer and some prior health conditions or measures of body size.