Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida.
Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida.
复制标题
德克萨斯州和佛罗里达州多重耐药粪肠球菌 ST6 中 Tn1549 介导的 vanB 万古霉素耐药性的多位点检测。
DOI：
10.1128/aac.01284-22
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发表时间：
2023
影响因子：
4.9
通讯作者：
Ari
中科院分区：
文献类型：
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作者：
Simar,ShelbyR;Tran,TrucT;Rydell,KirstenB;Panesso,Diana;Contreras,GermanA;Munita,JoseM;Cifuentes,RenzoO;Abbo,LilianM;Sahasrabhojane,Pranoti;Dinh,AnQ;Axell-House,DierdreB;Savidge,Tor;Shelburne,SamuelA;Hanson,BlakeM;Ari
在美国，肠球菌中vanB介导的耐药性很少见。我们的特点是三个序列类型（ST）6，万古霉素耐药粪肠球菌分离株引起菌血症的独特患者在时空不同的设置。2018年至2020年期间，在美国的两个城市（德克萨斯州休斯顿;佛罗里达州迈阿密）回收了分离株。这些菌株在染色体上的Tn 1549转座子上携带thevanB操纵子，流行病学数据表明，thevanB基因簇多次引入ST 6 E。粪便。
In the United States,vanB-mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored thevanBoperon on a chromosomally located Tn1549transposon, and epidemiological data suggested multiple introductions of thevanBgene cluster into ST6 E. faecalis.