Is fetal macrosomia related to blood pressure among adolescents? A birth cohort study in China
Is fetal macrosomia related to blood pressure among adolescents? A birth cohort study in China
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DOI：
10.1038/jhh.2013.31
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发表时间：
2013-11-01
影响因子：
2.7
通讯作者：
Rong, F.
中科院分区：
文献类型：
--
作者：
Li, Y.;Wu, J.;Rong, F.
出生体重（BW）对血压（BP）有影响。为了探讨巨大儿对儿童期和青少年期血压的影响，在中国无锡进行了一项纵向队列研究。1993-1995年出生的体重≥ 4000克的受试者为接触组;未接触组的比较按出生年份和婴儿性别匹配，体重为2500-4000克。2005-6年和2011-12年进行了随访，由训练有素的医生测量身高、体重和血压。采用SAS多元混合模型控制重复测量，探讨巨大胎儿对血压的影响。在队列开始时，招募了1595对参与者。最终，暴露组1112例和未暴露组1126例完成了两次随访。在青少年中，平均（s.d.）收缩压（SBP）为110.83（9.43）mm Hg，在统计学上显著高于未暴露组（平均值+/- s.d.：109.33 +/- 9.26）mm Hg（P = 0.0002）。在调整重复测量和出生年份、性别、母亲职业和分娩年龄、孕期增重、分娩期高血压、胎龄和产次、儿童期挑食等因素后，巨大儿组SBP高于正常体重组，参数估计值为1.03（s.e. = 0.30）。当儿童期的BMI和青少年期的BMI被添加到多模型中时，估计的β值为0.71（s.e. = 0.29）。在多元分析中，未发现巨大儿对青少年舒张压有统计学显著影响。
Birth weight (BW) has effects on blood pressure (BP). In order to explore the effects of macrosomia on BP in childhood and in adolescence, a longitudinal cohort study was conducted in Wuxi, China. Subjects with BW >= 4000 g, born in 1993-1995, were the exposed group; the unexposed comparisons were matched by year of birth and sex of infant, with BW of 2500-4000 g. Follow-ups in 2005-6 and 2011-12 were conducted, and height, weight and BP were measured by trained doctors. Multi-mixed models in SAS were used to control for repeated measures to explore the effects of fetal macrosomia on BP. At the inception of the cohort, 1595 pairs of participants were recruited. At the end, 1112 in the exposed group and 1126 in the unexposed group finished both follow-ups. Among adolescents, mean (s.d.) of systolic BP (SBP) was 110.83 (9.43) mm Hg, which was statistically significantly higher than that in the unexposed group (mean +/- s.d.: 109.33 +/- 9.26) mm Hg (P = 0.0002). After adjusting the repeated measures and birth year, sex, mother's occupation and delivery age, adding weight during pregnancy, hypertension during delivery, gestational age and parity, being a picky eater in childhood, the macrosomia group had higher SBP than the normal BW group; the parameter estimate value was 1.03 (s.e. = 0.30). When BMI in childhood and BMI in adolescence were added in the multi-model, the estimated beta was 0.71 (s.e. = 0.29). No statistically significant effect of macrosomia was found on diastolic BP among adolescents in the multianalysis.