Adverse gastrointestinal effects of NSAIDs: consequences and costs
Adverse gastrointestinal effects of NSAIDs: consequences and costs
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DOI：
10.1053/bega.2001.0232
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发表时间：
2001-10-01
影响因子：
3.2
通讯作者：
Gabriel, SE
中科院分区：
文献类型：
--
作者：
Bidaut-Russell, M;Gabriel, SE
非甾体抗炎药（NSAIDs）是一些最广泛使用的药物。它们可以通过处方和“非处方”购买。同样的药理学性质，使其在治疗各种疼痛和/或关节炎的条件下有效，负责各种胃肠道不良反应，从相对轻微的消化不良到潜在致命的胃肠道（GI）出血和穿孔溃疡。每年与使用非甾体抗炎药相关的胃肠道并发症的医疗费用非常高，并且可能随着美国人口老龄化的增长而增加。回顾了1970-2000年关于非甾体抗炎药相关胃肠道不良反应的后果和成本的文献，包括非甾体抗炎药的医源性成本因素。了解和比较不同人群和不同卫生保健系统中nsaid相关胃肠道不良反应的后果和成本对临床护理、药物经济学和政策领域具有重要意义。
Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most widely consumed medications. They are available by prescription and 'over the counter'. The same pharmacological properties which make them effective in the treatment of a variety of painful and/or arthritic conditions are responsible for a variety of adverse gastrointestinal effects, ranging from relatively mild dyspepsia to potentially lethal gastrointestinal (GI) bleeding and perforated ulcers. Yearly medical costs of GI complications associated with the use of NSAIDs are very high and likely to increase with the growth of the ageing US population. A review of the literature (1970-2000) on consequences and costs of NSAID-associated GI adverse effects, including iatrogenic cost factors of NSAIDs, was performed. The results were tabulated and compared, Knowledge and comparison of the consequences and costs of NSAID-associated GI adverse effects in various populations and across various health care systems are important for clinical care, pharmacoeconomics and policy arenas.