Sterioselective Synthesis of S-Linked 2-Deoxy Sugars
Sterioselective Synthesis of S-Linked 2-Deoxy Sugars
复制标题
DOI：
10.1055/s-0033-1340309
复制
发表时间：
2014-02-13
期刊：
影响因子：
2
通讯作者：
Zhu, Jianglong
中科院分区：
文献类型：
--
作者：
Baryal, Kedar N.;Zhu, Jianglong
S-连接的2-脱氧糖，天然存在的O-连接的2-脱氧糖的潜在非水解模拟物的立体选择性合成，仍然是一个挑战，由于在C2的导向基团的情况下。本文介绍了最近的努力，在立体选择性合成的S-连接的2-脱氧糖，包括我们的方法，涉及磺酰化的立体化学定义的2-脱氧糖基锂与不对称糖衍生的二硫化物。
Stereoselective synthesis of S-linked 2-deoxysugars, potentially nonhydrolyzable mimics of naturally occurring O-linked 2-deoxy sugars, remains a challenge due to the absence of a directing group at C2. This article describes recent efforts in the stereoselective synthesis of S-linked 2-deoxy sugars, including our approach which involves sulfenylation of stereochemically defined 2-deoxyglycosyl lithiums with asymmetric sugar-derived disulfides.