Mechanical and cold allodynia in a rat spinal cord contusion model.
Mechanical and cold allodynia in a rat spinal cord contusion model.
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大鼠脊髓挫伤模型中的机械性和冷性异常疼痛。
DOI：
10.1080/0899022042000201272
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Jacquin,MarkF
中科院分区：
文献类型：
--
作者：
Yoon,YoungWook;Dong,Hongxin;Arends,JoopJA;Jacquin,MarkF
本研究观察了大鼠脊髓挫伤后机械性痛觉超敏和冷痛感的时程变化。在不同严重程度的挫伤后，测量大鼠后爪对von Frey毛发刺激的撤退阈值和对丙酮的撤退频率。挫伤由10 g体重从6.2 5、12.5和2 5 mm下降。损伤后出现机械性和冷性超敏，这些组间的超敏发生率和戒断阈值有显著差异。最轻的损伤(6.25 mm)最一致地导致对机械刺激的后掌阈值降低和对冷的撤退频率增加。
This study examined the time course of mechanical and cold allodynia in rat hindpaw after spinal cord contusion. Hindpaw withdrawal threshold to graded von Frey hair stimulation and withdrawal frequency to acetone application were measured in rats subjected to contusions of varying severity, produced by a MASCIS impactor device with a 10 g weight dropped from 6.25, 12.5, or 25 mm. Mechanical and cold allodynia developed following the injury, and differences in the incidence of allodynia and in withdrawal threshold were significant among these groups. The least severe injury (6.25 mm) most consistently caused a decreased hindpaw threshold to mechanical stimulation and an increased withdrawal frequency to cold.