Discrimination ratio analysis of inflammatory markers: Implications for the study of inflammation in chronic disease
Discrimination ratio analysis of inflammatory markers: Implications for the study of inflammation in chronic disease
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DOI：
10.1016/j.metabol.2004.01.013
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发表时间：
2004-07-01
影响因子：
9.8
通讯作者：
Jebb, SA
中科院分区：
文献类型：
--
作者：
Browning, LM;Krebs, JD;Jebb, SA
为了了解炎症在慢性疾病中的作用，有一个可靠的测量习惯性炎症状态是很重要的。许多急性期反应标志物已被用作炎症状态的测量，但单一测量适当反映习惯性炎症状态的能力尚未得到评估。本研究比较了不同炎症标志物在超重女性中表征习惯性炎症状态的能力。从86名超重妇女(平均体重指数[BMI]， 35.2 kg/m(2)；测量范围26.2至47.6 kg/m(2))和一些炎症标志物（包括急性期反应标志物和细胞因子）。随机选择的15名妇女亚群在另外2个场合接受进一步的血液样本。使用亚群，计算每个炎症标志物的区分率（DRs），以评估受试者内的变异性。然后使用dr来确定这些标记之间的关系，并根据受试者内部的可变性在整个人群中进行调整。在这个高度控制的实验环境中，白细胞介素-6 （IL-6）的DR值为3.71，是区分受试者能力最强的细胞因子，这表明它最能表征习惯炎症状态。唾液酸是急性期反应标志物，DR最高（3.16），与其他炎症标志物（包括c反应蛋白（CRP））的相关性强于IL-6。这项研究表明，使用一些炎症标志物，如CRP，具有很大的个体变异性，会低估炎症和疾病之间的关系，因此炎症和慢性疾病之间的关系可能比以前认识到的更强。未来的研究应考虑IL-6或唾液酸，以提供更可靠的炎症状态测量。(C) 2004爱思唯尔公司版权所有。
To understand the role of inflammation in chronic disease it is important to have a reliable measure of habitual inflammatory status. A number of acute-phase response markers have been used as measures of inflammatory status, but the ability of a single measure to appropriately reflect habitual inflammatory status has not been assessed. This study compares the ability of different inflammatory markers to characterize habitual inflammatory status in overweight women. A single fasting blood sample was taken from 86 overweight women (mean body mass index [BMI], 35.2 kg/m(2); range, 26.2 to 47.6 kg/m(2)) and a number of inflammatory markers (both acute-phase response markers and cytokines) were measured. A randomly selected subpopulation of 15 women at-tended on 2 further occasions for further blood samples. Using the subpopulation, discrimination ratios (DRs) were calculated for each inflammatory marker to assess the within-subject variability. The DRs were then used to determine the relationship between these markers, adjusted for within-subject variability, in the whole population. In this highly controlled experimental environment, interleukin-6 (IL-6), with a DR of 3.71, was the cytokine with the greatest ability to discriminate between subjects, suggesting that it is best able to characterize habitual inflammatory status. Sialic acid was the acute-phase response marker with the highest DR (3.16), and showed stronger correlations with other inflammatory markers, including C-reactive protein (CRP), than IL-6. This study suggests that use of some inflammatory markers, such as CRP, with large within-individual variability, will underestimate the relationship between inflammation and disease, and thus relationships between inflammation and chronic disease may be stronger than previously appreciated. Future studies should consider IL-6 or sialic acid to provide a more robust measure of inflammatory status. (C) 2004 Elsevier Inc. All rights reserved.