The expression of EGFR family ligands in breast carcinomas
The expression of EGFR family ligands in breast carcinomas
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DOI：
10.1177/106689690201000202
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发表时间：
2002-04-01
影响因子：
1.2
通讯作者：
Nesland, JM
中科院分区：
文献类型：
--
作者：
Suo, ZH;Risberg, B;Nesland, JM
应用免疫组织化学方法检测100例冷冻乳腺癌组织中EGF、HB-EGF、TGF-α、HRG-α、HRG-β1、HRG-β3的表达。其中EGF阳性67%，HB-EGF阳性53%，TGF-α阳性57%，HRGA阳性60%，HRG-β1阳性53%，HRG-β3阳性63%。生长因子的表达与肿瘤大小、组织学分级、淋巴结状态、倍体、ER状态及c-erbB-4表达均无显著相关性，但EGF表达与肿瘤大小(P=0.01)、HRG-β3表达与淋巴结状态(P=0.02)有显著相关性。Kaplan Meier分析显示，这些生长因子的表达与癌症特异性生存无关。
Expression of EGF, HB-EGF, TGF-alpha, HRG-alpha, HRG-beta1, and HRG-beta3 in 100 frozen breast carcinoma materials was immunohistochemically studied. Among these tumors, 67% were positive for EGF, 53% for HB-EGF, 57% for TGF-alpha, 60% for HRGa, 53% for HRG-beta1, and 63% for HRG-beta3 in the neoplastic epithelial cells. No significant associations between expression of the growth factors and clinicopathological features like tumor size, histologic grade, node status, ploidy, ER status, and c-erbB-4 expression were observed, with the exceptions that significant relations were present between EGF expression and tumor size (p = 0.01) and between HRG-beta3 expression and node status (p = 0.02). The expressions of these growth factors showed no association with cancer-specific survival by the Kaplan Meier analysis.