RELATIONSHIP OF ANDROGENIC ACTIVITY TO BODY-FAT TOPOGRAPHY, FAT-CELL MORPHOLOGY, AND METABOLIC ABERRATIONS IN PREMENOPAUSAL WOMEN
RELATIONSHIP OF ANDROGENIC ACTIVITY TO BODY-FAT TOPOGRAPHY, FAT-CELL MORPHOLOGY, AND METABOLIC ABERRATIONS IN PREMENOPAUSAL WOMEN
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DOI：
10.1210/jcem-57-2-304
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发表时间：
1983-01-01
影响因子：
5.8
通讯作者：
KISSEBAH, AH
中科院分区：
文献类型：
--
作者：
EVANS, DJ;HOFFMANN, RG;KISSEBAH, AH
在上半身脂肪定位及其伴随的细胞和代谢特征的发病机制中，雄激素/雌激素活性增加可能起作用。对80名健康、非多毛、绝经前的高加索妇女进行了研究，她们的体脂形态[腰围/臀围比(WHR)为0.64~1.02]和肥胖水平(理想体重百分比为92~251%)变化较大。促雄激素能力的增加，反映为血浆性激素结合球蛋白能力的下降和游离睾酮百分比的增加，伴随着腰臀比的增加，这种关系独立于肥胖水平，并与肥胖水平相加；腹部而不是股骨脂肪细胞的大小增加；基础和口服葡萄糖负荷导致血糖和胰岛素水平增加；体内胰岛素敏感性降低，表现为通过注射生长抑素、胰岛素和葡萄糖，在相当的血浆胰岛素水平下增加稳态血糖水平。未发现血浆总睾酮、雄烯二酮、脱氢表雄酮硫酸盐或雌二醇浓度与腰围比、脂肪细胞大小或代谢特征之间的关联。显然，在绝经前的女性中，组织暴露于游离雄激素的相对增加可能是上半身脂肪定位、腹部脂肪细胞增大以及随之而来的葡萄糖-胰岛素稳态失衡的部分原因。
A possible role for increased androgenic/estrogenic activity in the pathogenesis of upper body fat localization and its accompanying cellular and metabolic characteristics was examined. Eighty healthy, nonhirsute, premenopausal caucasian women with a wide range of body fat topography [waist to hips girth ratio (WHR), 0.64 to 1.02] and obesity level (percentage of ideal body wt, 92-251%) were studied. Increasing androgenicity, as reflected by a decrease in plasma sex hormone-binding globulin capacity and an increase in the percentage of free testosterone, was accompanied by increasing WHR, this relationship being independent of and additive to that of obesity level; increasing size of abdominal, but not femoral, adipocytes; increasing plasma glucose and insulin levels, both basally and in response to oral glucose loading; and diminished in vivo insulin sensitivity, as revealed by increasing steady state plasma glucose levels at comparable plasma insulin levels, attained by the infusion of somatostatin, insulin and glucose. No association was found between total plasma testosterone, androstenedione, dehydroepiandrosterone sulfate or estradiol concentrations and WHR, fat cell size or metabolic profiles. Apparently, in premenopausal women, a relative increase in tissue exposure to unbound androgens may be responsible in part for localization of fat in the upper body, enlargement of abdominal adipocytes and the accompanying imbalance in glucose-insulin homeostasis.