Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock.
Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock.
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DOI：
10.1186/s40560-015-0123-2
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发表时间：
2016
影响因子：
7.1
通讯作者：
Sawamura A
中科院分区：
文献类型：
--
作者：
Jesmin S;Gando S;Wada T;Hayakawa M;Sawamura A
我们假设活化蛋白C不会增加创伤后弥散性血管内凝血（DIC），对于急性创伤休克凝血病（ACOTS）也是如此。前瞻性地测量了57例创伤患者的活化蛋白C水平：30例有DIC， 27例无DIC。与对照组和非DIC患者相比，DIC患者的活化蛋白C水平正常至更低。ACOTS患者的活化蛋白C水平与DIC患者相似。综上所述，在创伤早期DIC或ACOTS中，活化蛋白C均未增加。
We hypothesized that activated protein C does not increase in disseminated intravascular coagulation (DIC) after trauma and that the same is true for acute coagulopathy of trauma-shock (ACOTS). Activated protein C levels were prospectively measured in 57 trauma patients: 30 with DIC and 27 without DIC. Normal to more decreased activated protein C levels were observed in DIC patients than in the controls and non-DIC patients. The activated protein C levels in ACOTS patients were similar to those in DIC patients. In conclusion, activated protein C does not increase in either DIC or ACOTS in the early phase of trauma.