Depth profiling of 4-acetamindophenol-doped poly(lactic acid) films using cluster secondary ion mass spectrometry
Depth profiling of 4-acetamindophenol-doped poly(lactic acid) films using cluster secondary ion mass spectrometry
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DOI：
10.1021/ac035532n
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发表时间：
2004-06-01
影响因子：
7.4
通讯作者：
Gillen, G
中科院分区：
文献类型：
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作者：
Mahoney, CM;Roberson, SV;Gillen, G
探讨了使用团簇二次离子质谱法对药物递送系统进行深度剖析的可行性。研究了各种可生物降解聚合物薄膜在动态SF5⁺一次离子轰击下的行为，包括几种掺杂有模型药物的薄膜。从这些可生物降解聚合物薄膜获得的SF5⁺深度剖析图显示，二次离子信号随一次离子剂量增加而产生的衰减极小，并且发现对于高达约5×10¹⁵离子/平方厘米的离子剂量，聚合物的特征离子信号保持恒定。这些结果表明，此处所研究的可生物降解聚合物的聚酯结构由于主链易于断裂而具有更强的深度剖析能力。还尝试对一系列含有不同浓度的药物4 - 乙酰氨基酚的聚乳酸（PLA）薄膜进行深度剖析。从这些薄膜获得的深度剖析图显示，4 - 乙酰氨基酚分子离子和PLA碎片离子信号随SF5⁺一次离子剂量增加而产生的下降极小。在掺杂茶碱的PLA薄膜中也得到了类似结果。这些结果表明，在某些药物递送装置中，使用团簇一次离子束可以监测药物随深度的分布情况。
The feasibility of using cluster secondary ion mass spectrometry for depth profiling of drug delivery systems is explored. The behavior of various biodegradable polymer films under dynamic SF5+ primary ion bombardment was investigated, including several films doped with model drugs. The SF5+ depth profiles obtained from these biodegradable polymer films showed very little degradation in secondary ion signal as a function of increasing primary ion dose, and it was discovered that the characteristic ion signals for the polymers remained constant for ion doses up to similar to5 x 10(15) ions/cm(2). These results suggest that the polyester structure of the biodegradable polymers studied here allows for a greater ability to depth profile due to ease of main chain scission. Attempts were also made to depth profile through a series of poly(lactic acid) (PLA) films containing varying concentrations of the drug 4-acetamidophenol. The depth profiles obtained from these films show very little decrease in both the 4-acetamidophenol molecular ion and PLA fragment ion signals as a function of increasing SF5+ primary ion dose. Similar results were obtained with theophylline-doped PLA films. These results show that, in some drug delivery devices, it is possible to monitor the distribution of a drug as a function of depth by using cluster primary ion beams.