Relationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+T-cells in HIV infection
Relationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+T-cells in HIV infection
复制标题
DOI：
10.1183/09031936.00045509
复制
发表时间：
2010-03-01
影响因子：
24.3
通讯作者：
Lange, C.
中科院分区：
文献类型：
--
作者：
Leidl, L.;Mayanja-Kizza, H.;Lange, C.
艾滋病毒感染是非洲结核病的最大危险因素。皮肤试验（TST），QuantiFERON-TB Gold In-Tube在乌干达坎帕拉的一所大学门诊部，在新诊断的患有和不患有活动性TB的HIV感染个体和未感染HIV的受试者中进行TB测定。109例新诊断为HIV-1感染但无活动性TB，19例HIV-1感染和活动性TB，7例HIV未感染的健康受试者。在对照受试者中，TST检测免疫反应阳性率为57.2%，至少一种干扰素-γ释放测定免疫反应阳性率为100%。在无活动性TB的HIV-1感染患者中，TST硬结（mm）（rho=0.41，p值
Infection with HIV is the greatest risk factor for tuberculosis (TB) in Africa. Tuberculin skin test (TST), QuantiFERON-TB Gold In-Tube (QFT-G-IT) and T-Spot.TB assays were performed in newly diagnosed HIV-infected individuals with and without active TB and in HIV-uninfected subjects at a university outpatient clinic in Kampala, Uganda.A total of 135 individuals were enrolled: 109 with a new diagnosis of HIV-1 infection but no active TB, 19 with HIV-1 infection and active TB, and seven HIV-uninfected healthy subjects. In control subjects immune responses were positive in 57.2% by TST and in 100% by at least one interferon-gamma release assay.In HIV-1 infected patients without active TB, induration in the TST (mm) (rho=0.41, p-value