Myocardial Tissue Caveolae
Myocardial Tissue Caveolae
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DOI：
10.1002/cphy.c140050
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发表时间：
2015-04-01
影响因子：
5.8
通讯作者：
Jourdan-Le Saux, Claude
中科院分区：
文献类型：
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作者：
Sanon, Vani P.;Sawaki, Daigo;Jourdan-Le Saux, Claude
Caveolae and their coat proteins, caveolins (Cav), are cave-like invaginations found in the plasma membrane of a variety of cells.这些独特的囊泡及其外壳蛋白 Cavs 对内皮功能、一氧化氮合成调节、信号转导、胆固醇代谢和细胞凋亡具有多种影响。 Cav 基因敲除小鼠的动物研究证明了这些结构蛋白对内皮和血管功能的重要作用。遗传学研究表明，除了肿瘤之外，Cavs 可能在动脉粥样硬化、心肌病、长 QT 综合征、肺纤维化和肌营养不良症的发展中发挥作用。 The role of Cav expression in atherosclerotic disease is poorly understood and remains controversial.有趣的是，低 Cav-1 水平与易损斑块之间存在新的证据，这可能将 Cav-1 确定为一种新型斑块生物标志物。众所周知，Cavs 通过涉及内皮一氧化氮合酶和丝裂原激活蛋白激酶的复杂生化途径在多个层面上影响心血管系统。 In the present review, we aim to highlight the nature and types of caveolae, caveolar signaling mechanisms and regulation, and the pathophysiology of Cavs as it pertains to the cardiovascular system.需要持续的研究来阐明这些新型蛋白质的诊断和预后作用，并确定 Cavs 的作用如何转化为临床医学。 (C) 2015 年美国生理学会。
Caveolae and their coat proteins, caveolins (Cav), are cave-like invaginations found in the plasma membrane of a variety of cells. These unique vesicles and their coat proteins, Cavs, have diverse effects on endothelial function, nitric oxide synthesis regulation, signal transduction, cholesterol metabolism, and apoptosis. Animal studies in Cav knockout mice demonstrate the vital role of these structural proteins on endothelial and vascular function. Genetic studies have proposed that beside neoplasia, Cavs may play a role in the development of atherosclerosis, cardiomyopathy, long QT syndrome, pulmonary fibrosis, and muscular dystrophy. The role of Cav expression in atherosclerotic disease is poorly understood and remains controversial. Interestingly, there is emerging evidence between low Cav-1 levels and the vulnerable plaque, which could potentially identify Cav-1 as a novel plaque biomarker. Cavs, through intricate biochemical pathways involving endothelial nitric oxide synthase and mitogen-activated protein kinase, are known to affect the cardiovascular system at multiple levels. In the present review, we aim to highlight the nature and types of caveolae, caveolar signaling mechanisms and regulation, and the pathophysiology of Cavs as it pertains to the cardiovascular system. Ongoing research is needed to clarify the diagnostic and prognostic role of these novel proteins and to determine how the effects of Cavs can translate into clinical medicine. (C) 2015 American Physiological Society.