Effects of chemotherapy on pathologic and biologic characteristics of locally advanced breast cancer
Effects of chemotherapy on pathologic and biologic characteristics of locally advanced breast cancer
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DOI：
10.1093/ajcp/107.2.211
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发表时间：
1997-02-01
影响因子：
3.5
通讯作者：
VanDiest, PJ
中科院分区：
文献类型：
--
作者：
Honkoop, AH;Pinedo, HM;VanDiest, PJ
在42例局部晚期乳腺癌患者接受新辅助化疗，然后进行手术和放疗，化疗对肿瘤结构，形态计量学核和核仁特征，DNA倍体，增殖指数有丝分裂活性指数，分化抗原的表达和微血管密度的影响进行了研究。24例患者的治疗前活检标本可用于与乳房切除术标本进行比较，9例患者的锁骨下活检标本可用于化疗前。其余患者在化疗前进行细针穿刺，化疗后才能研究肿瘤的形态学和生物学特征。在23例患者中，化疗后仅留下显微镜下可见的肿瘤或无肿瘤，在这些患者中，我们观察到特征性模式的相对细胞纤维组织与淋巴细胞浸润，铁负载的巨噬细胞，以及，当存在时，分散的肿瘤细胞灶之间。我们发现，作为一个组，所有肿瘤的有丝分裂活性指数和整体微血管密度降低。然而，在核和核仁形态特征、DNA倍体和分化抗原表达方面没有一致的变化模式，也没有病理学或生物学特征可预测对化疗的反应。
In 42 patients with locally advanced breast cancer treated with neoadjuvant chemotherapy followed by surgery and radiation therapy, the effects of chemotherapy on tumor architecture, morphemetric nuclear and nucleolar characteristics, DNA ploidy, proliferation index measured by mitotic activity index, expression of differentiation antigens, and microvessel density were studied. Pretreatment biopsy specimens were available to compare with mastectomy specimens for 24 patients, and subclavicular biopsy specimens taken before chemotherapy were available for 9 patients. In the remaining patients, fine-needle aspiration was performed before chemotherapy, and morphologic and biologic features of the tumors could be studied only after chemotherapy. In 23 patients, only microscopic tumor or no tumor was left after chemotherapy, and in these patients we observed a characteristic pattern of relatively cellular fibrous tissue with lymphocytic infiltrate, iron-loaded macrophages, and, when present, scattered foci of tumor cells in between. We found a reduction in mitotic activity index and in global microvessel density over all the tumors as a group. There was, however, no consistent pattern of changes in nuclear and nucleolar morphometric characteristics, DNA ploidy, and expression of differentiation antigens, and no pathologic or biologic features were predictive for response to chemotherapy.