ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview
ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview
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DOI：
10.1016/j.toxicon.2017.12.046
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发表时间：
2018-07-01
期刊：
影响因子：
2.8
通讯作者：
Ladant, Daniel
中科院分区：
文献类型：
--
作者：
Belyy, Alexander;Mechold, Undine;Ladant, Daniel
ExoY是四种充分表征的铜绿假单胞菌3型分泌系统（T3SS）效应子之一。它是一种核苷酸环化酶毒素，在细菌内无活性，但一旦被递送到真核靶细胞中就被有效激活。最近，丝状肌动蛋白被鉴定为真核辅因子，其特异性地刺激ExoY酶活性几个数量级。在这篇综述中，我们讨论了最近的进展，了解生化的核苷酸环化酶活性的ExoY及其调控与丝状肌动蛋白的相互作用。(C)2017爱思唯尔有限公司版权所有
ExoY is one of four well-characterized Pseudomonas aeruginosa type 3 secretion system (T3SS) effectors. It is a nucleotidyl cyclase toxin that is inactive inside the bacteria, but becomes potently activated once it is delivered into the eukaryotic target cells. Recently, filamentous actin was identified as the eukaryotic cofactor that stimulates specifically ExoY enzymatic activity by several orders of magnitude. In this review, we discuss recent advances in understanding the biochemistry of nucleotidyl cyclase activity of ExoY and its regulation by interaction with filamentous actin. (C) 2017 Elsevier Ltd. All rights reserved.