BREAKDOWN OF THE BLOOD-CEREBROSPINAL FLUID BARRIER TO IMMUNOGLOBULIN IN MICE INJECTED INTRA-CEREBRALLY WITH A NEUROTROPIC INFLUENZA-A VIRUS - POST-EXPOSURE TREATMENT WITH MONOCLONAL-ANTIBODY PROMOTES RECOVERY
BREAKDOWN OF THE BLOOD-CEREBROSPINAL FLUID BARRIER TO IMMUNOGLOBULIN IN MICE INJECTED INTRA-CEREBRALLY WITH A NEUROTROPIC INFLUENZA-A VIRUS - POST-EXPOSURE TREATMENT WITH MONOCLONAL-ANTIBODY PROMOTES RECOVERY
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DOI：
10.1016/0165-5728(81)90027-8
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
GERHARD, W
中科院分区：
文献类型：
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作者：
DOHERTY, PC;GERHARD, W
通过在脑内[IC]接种A/WSN流感病毒2天后静脉注射0.5 mg病毒特异性单克隆抗血凝素抗体，可保护小鼠免受该病毒脑内[IC]接种的致命后果。通过比较血清和CSF中的特异性IG滴度来检查这些小鼠中血-CSF屏障的完整性。病毒生长的过程显然直接导致在IC暴露于病毒后63-96小时之间的某个时间血液-CSF屏障的实质性破坏。外源性给予的病毒特异性单克隆抗体并不明显参与消除这种生理屏障系统的完整性或促进炎症。事实上，对于不与病毒结合的抗体，在CSF中发现更高的IG滴度。CNS中的病毒感染细胞可能从CSF中吸附特异性IG。
Mice may be protected from the invariably fatal consequences of intracerebral [IC] inoculation of A/WSN influenza virus by i.v. injection with 0.5 mg of virus-specific monoclonal anti-hemagglutinin antibody given 2 days after IC challenge. The integrity of the blood-CSF barrier in such mice was examined by comparing specific Ig titers in serum and CSF. The process of virus growth evidently results directly in substantial breakdown of the blood-CSF barrier at some time between 63-96 h after IC exposure to virus. The exogenously administered, virus-specific monoclonal antibody is not obviously involved either in abrogating the integrity of this physiological barrier system or in promoting inflammation. In fact, higher Ig titers are found in CSF for an antibody that does not bind to the virus. Virus-infected cells in the CNS probably are adsorbing specific Ig from the CSF.