Depth-of-Interaction Compensation Using a Focused-Cut Scintillator for a Pinhole Gamma Camera.
Depth-of-Interaction Compensation Using a Focused-Cut Scintillator for a Pinhole Gamma Camera.
复制标题
使用针孔伽玛相机的聚焦切割闪烁体进行相互作用深度补偿。
DOI：
10.1109/tns.2011.2136386
复制
发表时间：
2011
影响因子：
1.8
通讯作者：
Nagarkar,VivekV
中科院分区：
文献类型：
--
作者：
Alhassen,Fares;Kudrolli,Haris;Singh,Bipin;Kim,Sangtaek;Seo,Youngho;Gould,RobertG;Nagarkar,VivekV
Preclinical SPECT offers a powerful means to understand the molecular pathways of drug interactions in animal models by discovering and testing new pharmaceuticals and therapies for potential clinical applications. A combination of high spatial resolution and sensitivity are required in order to map radiotracer uptake within small animals. Pinhole collimators have been investigated, as they offer high resolution by means of image magnification. One of the limitations of pinhole geometries is that increased magnification causes some rays to travel through the detection scintillator at steep angles, introducing parallax errors due to variable depth-of-interaction in scintillator material, especially towards the edges of the detector field of view. These parallax errors ultimately limit the resolution of pinhole preclinical SPECT systems, especially for higher energy isotopes that can easily penetrate through millimeters of scintillator material. A pixellated, focused-cut (FC) scintillator, with its pixels laser-cut so that they are collinear with incoming rays, can potentially compensate for these parallax errors and thus improve the system resolution. We performed the first experimental evaluation of a newly developed focused-cut scintillator. We scanned a Tc-99 m source across the field of view of pinhole gamma camera with a continuous scintillator, a conventional “straight-cut” (SC) pixellated scintillator, and a focused-cut scintillator, each coupled to an electron-multiplying charge coupled device (EMCCD) detector by a fiber-optic taper, and compared the measured full-width half-maximum (FWHM) values. We show that the FWHMs of the focused-cut scintillator projections are comparable to the FWHMs of the thinner SC scintillator, indicating the effectiveness of the focused-cut scintillator in compensating parallax errors.
