TIRANDALYDIGIN, A NOVEL TETRAMIC ACID OF THE TIRANDAMYCIN-STREPTOLYDIGIN TYPE .1. TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY
TIRANDALYDIGIN, A NOVEL TETRAMIC ACID OF THE TIRANDAMYCIN-STREPTOLYDIGIN TYPE .1. TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY
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DOI：
10.7164/antibiotics.45.1125
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发表时间：
1992-07-01
影响因子：
3.3
通讯作者：
HUMPHREY, PE
中科院分区：
文献类型：
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作者：
KARWOWSKI, JP;JACKSON, M;HUMPHREY, PE
替兰地丁是一种新的四酸抗生素，它是在一项旨在寻找具有抗致病厌氧菌活性的化合物的筛选中发现的。它被命名为替兰地菌素，因为它具有替兰霉素和链溶菌素共同的结构特征。产生菌AB 1006A-9是一株链霉菌，与合成替兰霉素和链溶菌素的链霉菌进行了比较。它与以前的培养密切相关，被命名为铁链霉菌亚种。乌米德斯。Tirandalydigin对许多致病厌氧菌、链球菌、肠球菌和军团菌的MIC在0.5至32mU/ml之间。
Tirandalydigin is a new tetramic acid antibiotic which was discovered in a screen designed to find compounds with activity against pathogenic anaerobic bacteria. It was named tirandalydigin because it possesses structural features that are common to both tirandamycin and streptolydigin. The producing culture, strain AB 1006A-9, is a Streptomyces and was compared to the streptomycetes that synthesize tirandamycin and streptolydigin. It is closely related to the former culture and was named Streptomyces tirandis subsp. umidus. Tirandalydigin has MICs in the range of 0.5 to 32-mu-g/ml against many pathogenic anaerobes, streptococci, enterococci and legionellae.