Effect of Tandospirone, a Partial Agonist of the 5-HT1A Receptor, in a Patient With Chronic Poststroke Emotional Incontinence With Anxiousness.
Effect of Tandospirone, a Partial Agonist of the 5-HT1A Receptor, in a Patient With Chronic Poststroke Emotional Incontinence With Anxiousness.
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DOI：
10.4088/pcc.18l02403
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发表时间：
2019-09
影响因子：
--
通讯作者：
Takehiro Tamura;Hiroki Shiwaku;Daisuke Jitoku;A. Kurumaji
中科院分区：
文献类型：
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作者：
Takehiro Tamura;Hiroki Shiwaku;Daisuke Jitoku;A. Kurumaji
引用：Tamura T， Shiwaku H， Jitoku D等。坦多螺酮，5-HT1A受体的部分激动剂，在慢性卒中后情绪失禁伴焦虑患者中的作用中枢神经系统疾病的护理伴发[j] . 2019;21(5): 18102403。分享：https://doi.org/10.4088/PCC.18l02403©版权所有2019 Physicians Postgraduate Press， Inc。脑卒中后可能出现M和情绪障碍，可分为几种临床表型卒中后情绪失禁（PSEI）是这些临床表型之一，其特征是过度和不适当的情绪表达。最近的一篇综述认为，涉及从中叶核上升到半球的血清素能纤维的损伤可能在PSEI的发病机制中很重要，并且选择性血清素再摄取抑制剂（SSRIs）对急性或亚急性患者的PSEI治疗有效。然而，据我们所知，没有关于慢性PSEI患者的报告。我们报告了一个病例，其中坦多螺酮，5-羟色胺- 1a （5-HT1A； 5-羟色胺- 1a）受体的部分激动剂，对中风后ssri抵抗性慢性情绪失禁伴焦虑的患者有效。该药物与丁螺环酮和庚螺环酮一样，属于阿扎哌酮类药物。
To cite: Tamura T, Shiwaku H, Jitoku D, et al. Effect of tandospirone, a partial agonist of the 5-HT1A receptor, in a patient with chronic poststroke emotional incontinence with anxiousness. Prim Care Companion CNS Disord. 2019;21(5):18l02403. To share: https://doi.org/10.4088/PCC.18l02403 © Copyright 2019 Physicians Postgraduate Press, Inc. M and emotional disturbances might occur after a stroke and can be classified into several clinical phenotypes.1 Poststroke emotional incontinence (PSEI) is one of these clinical phenotypes and is characterized by excessive and inappropriate emotional expressions. A recent review1 posited that damage involving serotonergic fibers ascending from the raphe nuclei to the hemispheres is probably important in the pathogenesis of PSEI, and administration of selective serotonin reuptake inhibitors (SSRIs) is effective in treating PSEI in acute or subacute patients. To the best of our knowledge, however, there are no reports about patients with a chronic course of PSEI. We report a case in which tandospirone,2 a partial agonist of the 5-hydroxytryptamine-1A (5-HT1A; serotonin-1A) receptor, was effective for a poststroke patient with SSRI-resistant chronic emotional incontinence with anxiousness. The drug is a member of the azapirone class of drugs such as buspirone and gepirone.