DYNAMICS OF PLASMA-CATECHOLAMINE AND CORTICOSTERONE CONCENTRATIONS DURING REINFORCED AND EXTINGUISHED OPERANT-BEHAVIOR IN RATS
DYNAMICS OF PLASMA-CATECHOLAMINE AND CORTICOSTERONE CONCENTRATIONS DURING REINFORCED AND EXTINGUISHED OPERANT-BEHAVIOR IN RATS
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DOI：
10.1016/0031-9384(90)90079-j
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发表时间：
1990-04-01
影响因子：
2.9
通讯作者：
VANDERGUGTEN, J
中科院分区：
文献类型：
--
作者：
DEBOER, SF;DEBEUN, R;VANDERGUGTEN, J
在永久性心脏插管大鼠进行强化和非强化（熄灭）操作行为之前和期间，同时测定血浆去甲肾上腺素（NA）、肾上腺素（A）和皮质酮（CS）浓度。前不久，实验性的食物强化（VI 15秒的时间表）按下任务，预期的血浆NA和CS含量的升高进行了观察。增强后的水平反应过程中，血浆NA升高，A无变化，CS下降。灭绝与A的短暂增加、NA的降低和CS浓度的升高有关。此外，个体血压升高率、神经交感神经和肾上腺髓质反应性与程序诱导的烦渴程度之间存在相关性。结果表明，预期的行为后果（可控性和失控，分别）的存在和不存在出席了选择性，但高度分离的神经交感神经，肾上腺髓质和肾上腺皮质输出的模式。总的来说，这些发现加强了这样一个概念，即不同的情绪和/或动机状态与不同的神经内分泌反应模式有关。交感肾上腺髓质成分的反应性在很大程度上取决于大鼠的个体行为策略。
Plasma noradrenaline (NA), adrenaline (A) and corticosterone (CS) concentrations were determined simulataneously in permanently heart-cannulated rats before and during the performance of reinforced and nonreinforced (extinguished) operant behavior. Shortly before the experimental food-reinforced (VI 15-sec schedule) lever-pressing task, anticipatory elevations of plasma NA and CS contents were observed. During reinforced lever responding plasma NA increased, A did not change and CS declined. Extinction was associated with a transient increase in A, decreasing NA and elevated CS concentrations. In addition, a relationship was found between individual lever-pressing rate, neurosympathetic and adrenomedullary reactivity and the degree of schedule-induced polydipsia. The results indicate that presence and absence of expected behavioral consequences (controllability and loss of control, respectively) are attended by selective, but highly dissociated patterns of neurosympathetic, adrenomedullary and adrenocortical output. Collectively, the findings reinforce the concept that distinctive emotional and/or motivational states are associated with different patterns of neuroendocrine responses. The reactivity of the sympathoadrenomedullary component is heavily dependent upon a rat's individual behavioral strategy.