Prevalence of Schistosoma japonicum infection among animals in fifty villages of Samar Province, the Philippines
Prevalence of Schistosoma japonicum infection among animals in fifty villages of Samar Province, the Philippines
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DOI：
10.1089/vbz.2006.0565
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发表时间：
2007-06-01
影响因子：
2.1
通讯作者：
Carabin, H.
中科院分区：
文献类型：
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作者：
Fernandez, T. J., Jr.;Tarafder, M. R.;Carabin, H.
在菲律宾，有必要更好地了解不同的家畜和野生动物在将日本血吸虫感染传播给人类方面的作用。目前的研究描述了动物S.在菲律宾萨马尔省的50个流行村的日本血吸虫病流行。共选定了50个村庄，其中25个村庄主要靠雨水灌溉，25个村庄有一些灌溉系统。每个村庄至少随机选择35只猫、狗、猪和水牛，并设置30个捕鼠器。每种属的粪便样本最多连续采集3天。采用丹麦血吸虫病实验室方法（DBL法）检测血吸虫。日本血吸虫感染状况采用分层Logistic回归模型，按村庄进行聚类，并对DBL方法的测量误差进行调整，以估计每个村庄和物种的感染率。粪便样本分别采集自23.4%（1189）、28.6%（1274）、36.3%（1899）和49.4%（873）的普查犬、猫、猪和水牛以及663只大鼠。S.日本血吸虫感染在不同村庄之间差异很大，（95%贝叶斯可信区间：0.1%-10.2%）至86.3%（65.9%-97.8%）犬，从0.1%（0%-2.1%）至21.7%（4.7%-51.2%）猫，从0.01%（0.0%-1.0%）至18.4%（7.1%-34.7%）猪，从不到0.1%水牛为0.0%~ 1.2%，大鼠为0.7%~ 95.4%，水牛为46.0%~ 97.4%;这是对动物S.日本血吸虫感染。我们的研究结果表明，与中国报道的情况不同，很少有水牛感染，而大鼠和犬的感染率很高。这一点，结合显着村与村之间的变化，流行的S。japonicum感染，表明在菲律宾和中国的萨马省的感染可能不同的传播动力学。
In the Philippines, there is a need to understand the contribution of different domestic and wild animals in transmitting Schistosoma japonicum infection to humans better. The current study describes variation in animal S. japonicum prevalence across 50 endemic villages of Samar Province, the Philippines. A total of 50 villages were selected, 25 with predominantly rain-fed farms and 25 with some irrigation system. At least 35 cats, dogs, pigs, and water buffaloes each were randomly selected and 30 rat traps were set in each village. Fecal samples were collected for up to three consecutive days for each species. The Danish Bilharziasis Laboratory method (DBL method) was used to determine S. japonicum infection status. A hierarchical logistic regression model with clustering by village and with adjustment for measurement error of the DBL method was used to estimate the prevalence of infection per village and species. Stool samples were collected from 23.4% (1189), 28.6% (1274), 36.3% (1899), and 49.4% (873) of the censused dogs, cats, pigs, and water buffaloes, respectively, and from 663 rats. The adjusted prevalence of S. japonicum infection varied greatly across villages ranging from 1.6% (95% Bayesian Credible Interval: 0.1%-10.2%) to 86.3% (65.9%-97.8%) for dogs, from 0.1% (0%-2.1%) to 21.7% (4.7%-51.2%) for cats, from 0.01% (0.0%%-1.0%) to 18.4% (7.1%-34.7%) for pigs, from less than 0.1% (0.0%-1.2%) to 72.5% (46.0%-97.4%) for water buffaloes, and from 0.7% (0.0%-9.0%) to 95.4% (77.2%-99.9%) for rats. This is the most comprehensive study of animal S. japonicum infection conducted to date. Our results show that, unlike what has been reported in China, very few water buffaloes were infected whereas rats and dogs show high prevalence proportions of infection. This, combined with significant village-to-village variation in prevalence of S. japonicum infection, suggest possible different transmission dynamics of the infection in the Province of Samar in the Philippines and China.