Effects of a novel therapeutic diet on liver enzymes and coagulating factors in patients with non-alcoholic fatty liver disease: A parallel randomized trial
Effects of a novel therapeutic diet on liver enzymes and coagulating factors in patients with non-alcoholic fatty liver disease: A parallel randomized trial
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DOI：
10.1016/j.nut.2013.11.008
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发表时间：
2014-07-01
期刊：
影响因子：
4.4
通讯作者：
Azadbakht, Leila
中科院分区：
文献类型：
--
作者：
Kani, Ali Hashemi;Alavian, Seyed Moayed;Azadbakht, Leila
目的：有一些关于治疗性饮食在非酒精性脂肪性肝病（NAFLD）患者中的作用的报道。因此，本研究的目的是确定低热量、低碳水化合物含大豆饮食对NAFLD患者血脂、肝酶和凝血因子的影响。方法：这是一项随机平行临床试验，纳入45例NAFLD患者。参与者在8周内食用三种饮食。患者被随机分配低热量饮食；低热量、低碳水化合物饮食；或者低热量，低碳水化合物的大豆饮食。测量按标准方法进行。结果：三组患者体重变化无明显差异。低热量、低碳水化合物含大豆饲粮可降低丙氨酸转氨酶（-15.2 +/- 12.1，低热量、低碳水化合物饲粮为-6.8 +/- 4.6，低热量饲粮为-6.4 +/- 4.4 IU/L, P = 0.02）和血清纤维蛋白原水平（-49.1 +/- 60.1，低热量、低碳水化合物饲粮为-12.9 +/- 8.1和-17.4 +/- 8.4 g/L, P = 0.01）。在低热量、低碳水化合物含大豆组中，天冬氨酸转氨酶的减少明显更高。脂质谱的变化在两组之间没有显著差异。与其他饲粮相比，含大豆饲粮降低丙二醛的效果显著（P = 0.01）。结论：低热量、低碳水化合物含大豆饮食可能对NAFLD患者的肝酶、丙二醛和血清纤维蛋白原水平有有益的影响。(C) 2014爱思唯尔公司版权所有。
Objective: There are several reports regarding the role of therapeutic diets for patients with non-alcoholic fatty liver disease (NAFLD). Therefore, the aim of this study was to determine the effects of a low-calorie, low-carbohydrate soy-containing diet on lipid profiles, liver enzymes, and coagulating factors in patients with NAFLD.Method: This was a randomized parallel clinical trial involving 45 patients with NAFLD. The participants consumed three kinds of diets for 8 wk. Patients were randomly assigned to consume a low-calorie diet; a low-calorie, low-carbohydrate diet; or a low-calorie, low-carbohydrate soycontaining diet. Measurements were done according to the standard method.Results: Changes in weight were not significantly different in the three groups. The low-calorie, low-carbohydrate soy-containing diet could reduce alanine aminotransferase (-15.2 +/- 12.1 versus -6.8 +/- 4.6 in the low-calorie, low-carbohydrate diet, and -6.4 +/- 4.4 IU/L in the low-calorie diet; P = 0.02) and serum fibrinogen levels (-49.1 +/- 60.1 versus -12.9 +/- 8.1 and -17.4 +/- 8.4 g/L, respectively; P = 0.01). Reductions in aspartate aminotransferase were significantly higher in the low-calorie, low-carbohydrate soy-containing group. Changes in lipid profiles did not differ significantly between the groups. The soy-containing diet did reduce malondialdehyde more than the other diets (P = 0.01).Conclusion: A low-calorie, low-carbohydrate soy-containing diet could have beneficial effects on liver enzymes, malondialdehyde, and serum fibrinogen levels in patients with NAFLD. (C) 2014 Elsevier Inc. All rights reserved.