Human neocortical electrical activity recorded on nonpenetrating microwire arrays: applicability for neuroprostheses.
Human neocortical electrical activity recorded on nonpenetrating microwire arrays: applicability for neuroprostheses.
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DOI：
10.3171/2009.4.focus0974
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发表时间：
2009-07
影响因子：
4.1
通讯作者：
Greger B
中科院分区：
文献类型：
--
作者：
Kellis SS;House PA;Thomson KE;Brown R;Greger B
这项研究的目的是确定一个非穿透性、高密度的微线阵列是否可以提供足够的信息来作为解码运动皮质信号的接口。在2名患者的大脑运动皮质上植入了非穿透性微丝阵列。这些患者在两个方向上进行了定向的刻板运动。所得到的数据被用来确定是否可以通过频率功率分析来区分到达方向。相关分析表明，随着距离的增加，信号的相关性逐渐降低。运动规划中的伽马频段功率允许在到达运动中对粗略方向性进行二进制分类。功率变化的程度与潜在的脑回模式相关。非穿透性微丝平台显示出很好的潜力，可以在不穿透大脑皮层的情况下以高空间保真度记录区分信号。
The goal of this study was to determine whether a nonpenetrating, high-density microwire array could provide sufficient information to serve as the interface for decoding motor cortical signals. Arrays of nonpenetrating microwires were implanted over the human motor cortex in 2 patients. The patients performed directed stereotypical reaching movements in 2 directions. The resulting data were used to determine whether the reach direction could be distinguished through a frequency power analysis. Correlation analysis revealed decreasing signal correlation with distance. The gamma-band power during motor planning allowed binary classification of gross directionality in the reaching movements. The degree of power change was correlated to the underlying gyral pattern. The nonpenetrating microwire platform showed good potential for allowing differentiated signals to be recorded with high spatial fidelity without cortical penetration.