One-Pot Multicomponent Synthesis of β-Amino Amides
One-Pot Multicomponent Synthesis of β-Amino Amides
复制标题
β-氨基酰胺的一锅多组分合成
DOI：
10.1002/anie.201700840
复制
发表时间：
2017-04-10
影响因子：
16.6
通讯作者：
Cui, Sunliang
中科院分区：
文献类型：
--
作者：
Huang, Bo;Zeng, Linwei;Cui, Sunliang
Multicomponent reactions are excellent tools for rapid generation of small molecules with broad chemical diversity and molecular complexity. Herein, a novel one-pot multicomponent synthesis of beta-amino amides from aldehydes, anilines, carboxylic acids and ynamides has been successfully developed. This process is practical and efficient to unravel synthetic utility and scalability. Moreover, an isotope labeling reaction was conducted to elucidate a plausible reaction mechanism.
