Preexposure to nicotine alters the subsequent locomotor stimulant effects of bupropion in rats.
Preexposure to nicotine alters the subsequent locomotor stimulant effects of bupropion in rats.
复制标题
预先接触尼古丁会改变安非他酮对大鼠随后的运动刺激作用。
DOI：
10.1080/14622200500484642
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Bevins,RickA
中科院分区：
文献类型：
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作者：
Wilkinson,JamieL;Palmatier,MatthewI;Bevins,RickA
人们对尼古丁和安非他酮之间的相互作用知之甚少，但许多研究表明，它们在神经和行为上有相似之处。具有共同特征的药物的一个特征是能够交叉敏感，可能是通过奖励路径中的神经变化。这一通路的激活可能解释了安非他酮作为戒烟助剂的有效性。目前的研究调查了反复服用尼古丁是否改变了安非他酮随后的运动效果。在实验1中，大鼠在家中的笼子里8次预先暴露于尼古丁(0.4 mg/kg皮下)或生理盐水，然后在活动室内测试安非他酮(0，20或30 mg/kg)。尼古丁预暴露可增强30 mg/kg安非他酮的急性兴奋作用。在实验2中，大鼠反复接受尼古丁与运动室或家庭笼子的配对。在药室配对组中，急性安非他酮和尼古丁条件性多动之间存在相加效应。这种安非他酮急性运动效应的增强可能反映了常见的多巴胺能过程的改变。
Little is known about the interaction between nicotine and bupropion (Zyban), but many studies suggest they have neurological and behavioral similarities. One feature of drugs with common profiles is the ability to cross-sensitize possibly through neurological changes in the reward pathway. Activation of this pathway might explain the effectiveness of bupropion as a smoking cessation aid. The present research investigated whether repeated nicotine administration altered the subsequent locomotor effects of bupropion. In experiment 1, rats were preexposed to nicotine (0.4 mg/kg subcutaneously) or saline on eight separate occasions in the home cage and then tested with bupropion (0, 20, or 30 mg/kg) in locomotor chambers. The acute stimulant effect of 30 mg/kg of bupropion was potentiated by nicotine preexposure. In experiment 2, rats received nicotine repeatedly paired with the locomotor chambers or home cages. An additive effect was observed between acute bupropion and nicotine-conditioned hyperactivity in the chamber-paired group. This enhancement of the acute locomotor effects of bupropion might reflect alterations in common dopaminergic processes.