Circular RNAs in colorectal cancer: Possible roles in regulation of cancer cells.
Circular RNAs in colorectal cancer: Possible roles in regulation of cancer cells.
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DOI：
10.4251/wjgo.v9.i2.62
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发表时间：
2017-02-15
影响因子：
3
通讯作者：
Bernal G
中科院分区：
文献类型：
--
作者：
Taborda MI;Ramírez S;Bernal G
结直肠癌（CRC）是世界上第三大最常诊断的癌症，也是世界上第四大癌症死亡原因。目前，缺乏低成本、无创的结直肠癌筛查方法，成为严重的健康问题。在这种背景下，一种早期发现结直肠癌的潜在生物标志物最近引起了人们的关注。环状RNA （circRNA）是一种重新发现的丰富的RNA物种，是一种由外显子和内含子序列组成的非编码共价封闭RNA。这些环状分子在细胞中广泛表达，超过了传统的线性mRNA转录物的丰度。它们可以调节基因表达，作为mirna的真正海绵，也可以调节选择性剪接或作为转录因子和蛋白质的包容性编码。然而，人们对circRNA及其与CRC的关系知之甚少。在这篇综述中，我们将重点关注这些环状rna在结直肠癌中的生物发生、功能和作用，包括它们作为一种新的生物标志物的潜力。
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world and the fourth principal cause of cancer deaths worldwide. Currently, there is a lack of low cost and noninvasive screening tests for CRC, becoming a serious health problem. In this context, a potential biomarker for the early detection of CRC has recently gained attention. Circular RNAs (circRNA), a re-discovered, abundant RNA specie, is a type of noncoding covalent closed RNAs formed from both exonic and intronic sequences. These circular molecules are widely expressed in cells, exceeding the abundance of the traditional linear mRNA transcript. They can regulate gene expression, acting as real sponges for miRNAs and also regulate alternative splicing or act as transcriptional factors and inclusive encoding for proteins. However, little is known about circRNA and its relationship with CRC. In this review, we focus on the biogenesis, function and role of these circRNAs in relation to CRC, including their potential as a new biomarker.