Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells.
Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells.
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DOI：
10.1021/nl802098g
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发表时间：
2008-12
期刊：
影响因子：
10.8
通讯作者：
Adair JH
中科院分区：
文献类型：
--
作者：
Kester M;Heakal Y;Fox T;Sharma A;Robertson GP;Morgan TT;Altinoğlu EI;Tabaković A;Parette MR;Rouse SM;Ruiz-Velasco V;Adair JH
能更高效地将药物递送至癌性病变的范式转换模式需要具备以下特性：纳米级尺寸、靶向性以及在生理条件下的稳定性。通常，这些纳米级药物递送载体因团聚、溶解性差或细胞毒性而受到限制。因此，我们设计了一种方法，将疏水性抗肿瘤化疗药物包裹在直径为20 - 30纳米、具有pH响应性、不团聚且无毒的磷酸钙纳米颗粒基质中。在本研究中，我们报道了磷酸钙纳米复合颗粒（CPNP），它既能包裹荧光团又能包裹化疗药物，在37°C的生理溶液中能长时间保持胶体稳定性，并且能够在几种细胞模型系统中有效地递送疏水性抗肿瘤药物，如神经酰胺。
Paradigm-shifting modalities to more efficiently deliver drugs to cancerous lesions require the following attributes: nanoscale-size, targetability and stability under physiological conditions. Often, these nanoscale drug delivery vehicles are limited due to agglomeration, poor solubility or cytotoxicity. Thus, we have designed a methodology to encapsulate hydrophobic antineoplastic chemotherapeutics within a 20-30 nm diameter, pH-responsive, non-agglomerating, non-toxic calcium phosphate nanoparticle matrix. In the present study, we report on calcium phosphate nanocomposite particles (CPNP) that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for extended time at 37°C and can efficaciously deliver hydrophobic antineoplastic agents, such as ceramide, in several cell model systems.