Distances between real-world locations are represented in the human hippocampus.
Distances between real-world locations are represented in the human hippocampus.
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DOI：
10.1523/jneurosci.4667-10.2011
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发表时间：
2011-01-26
期刊：
影响因子：
--
通讯作者：
Epstein RA
中科院分区：
文献类型：
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作者：
Morgan LK;Macevoy SP;Aguirre GK;Epstein RA
空间导航被认为部分是通过参考环境的内部地图来引导的。我们使用功能性磁共振成像（fMRI）来测试认知地图的一个关键方面：真实世界距离关系的保留。大学生们在观看熟悉的校园地标照片时被扫描。左侧海马的fMRI反应水平与连续试验中显示的地标之间的真实距离相对应，表明该区域认为较近的地标更具代表性相似，而较远的地标更具代表性不同。与此相反，后部视觉反应区域，如压后复合体（RSC）和海马旁位置区（PPA）是敏感的地标重复和编码的地标身份在其多体素活动模式，但没有显示出距离相关的反应。这些数据表明，人类内侧颞叶中存在一种类似地图的表示，它对大规模真实世界环境中熟悉位置的坐标进行编码。
Spatial navigation is believed to be guided in part by reference to an internal map of the environment. We used functional magnetic resonance imaging (fMRI) to test for a key aspect of a cognitive map: preservation of real-world distance relationships. University students were scanned while viewing photographs of familiar campus landmarks. fMRI response levels in the left hippocampus corresponded to real-world distances between landmarks shown on successive trials, indicating that this region considered closer landmarks to be more representationally similar and more distant landmarks to be more representationally distinct. In contrast, posterior visually-responsive regions such as retrosplenial complex (RSC) and the parahippocampal place area (PPA) were sensitive to landmark repetition and encoded landmark identity in their multivoxel activity patterns but did not show a distance-related response. These data suggest the existence of a map-like representation in the human medial temporal lobe that encodes the coordinates of familiar locations in a large-scale, real-world environment.