Molecular characterization of attenuated Junin virus strains
Molecular characterization of attenuated Junin virus strains
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DOI：
10.1099/0022-1317-78-7-1605
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发表时间：
1997-07-01
影响因子：
3.8
通讯作者：
Romanowski, V
中科院分区：
文献类型：
--
作者：
Albarino, CG;Ghiringhelli, PD;Romanowski, V
朱宁病毒株Candid#1是作为阿根廷出血热减毒活疫苗开发的。本文报道了Candid#1及其致病力更强的祖先XJ#44和XJ（原型）的S RNA核苷酸序列。它们与朱宁病毒野生型MC 2株和其他近缘和远缘沙粒病毒的关系也进行了检查。比较Candid#1及其祖先菌株的N和GPC基因的核苷酸和氨基酸序列，发现了疫苗菌株特有的一些变化。这些变化可能暂时与减毒表型相关。
The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.