Solitary fibrous tumor: A study of cytologic features of six cases diagnosed by fine-needle aspiration
Solitary fibrous tumor: A study of cytologic features of six cases diagnosed by fine-needle aspiration
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DOI：
10.1002/dc.2032
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发表时间：
2001-09-01
影响因子：
1.3
通讯作者：
Nascimento, AG
中科院分区：
文献类型：
--
作者：
Clayton, AC;Salomao, DR;Nascimento, AG
孤立性纤维瘤（SFT）是一种梭形细胞肿瘤，最常表现为胸膜肿瘤，但在其他部位也越来越多地被发现。很少有报道描述SFT的细胞学特征。在马约诊所的文件中确定了6例细针穿刺诊断的SFT（3例胸膜，2例腹膜后，1例眼眶）。对涂片（巴氏染色）和相应的组织学标本进行了审查。所有病例均行CD 34免疫组化染色。所有病例的细胞学结果相似。肿瘤细胞呈椭圆形至多边形，细胞密度从少到中等。背景中含有不规则的胶原纤维碎片和少量炎性细胞。大多数细胞分散在单个，但所有情况下包含不规则的，松散的细胞聚集在胶原基质中。细胞核呈均匀的淡黄色，染色质分布均匀，呈细颗粒状。所有病例均为CD 34免疫反应阳性。SFT具有独特的细胞学特征，可以在伴随组织活检标本的适当免疫细胞化学染色的帮助下在细胞学标本中进行诊断。未发现可预测临床行为的独特细胞学结果。(C)2001 Wiley-Liss，Inc.
Solitary fibrous tumor (SFT) is a spindle-cell neoplasm most often presenting as a pleural-based tumor but increasingly recognized in other locations. Few reports have described the cytologic features of SFTs. Six cases of SFT diagnosed by fine-needle aspiration (3 pleura, 2 retroperitoneum, and I orbit) were identified in the Mayo Clinic files. The smears (Papanicolaou-stained) and corresponding histologic specimens were reviewed. Immunohistochemical staining for CD34 was performed in all cases. The cytologic findings were similar in all cases. The tumor cells were oval to polygonal, with cellularity ranging from scant to moderate. The background contained irregular ropy fragments of collagen and a few inflammatory cells. Most cells were dispersed singly, but all cases contained irregular, loose aggregates of cells enmeshed in a collagenous matrix. The nuclei were uniformly bland, with evenly distributed, finely granular chromatin. All cases were immunoreactive for CD34. SFT has distinctive cytologic features that allow diagnosis in cytologic specimens with the help of appropriate immunocytochemical stains on accompanying tissue biopsy specimens. Distinctive cytologic findings predictive of clinical behavior were not identified. (C) 2001 Wiley-Liss, Inc.