Insular cortex lesions and morphine-induced suppression of conditioned stimulus intake in the rat.
Insular cortex lesions and morphine-induced suppression of conditioned stimulus intake in the rat.
复制标题
岛叶皮质损伤和吗啡诱导的大鼠条件刺激摄入抑制。
DOI：
10.1037/a0014308
复制
发表时间：
2009
影响因子：
1.9
通讯作者：
Reilly,Steve
中科院分区：
文献类型：
--
作者：
Roman,Christopher;Reilly,Steve
本实验研究了在以吗啡为无条件刺激的消费过程中，岛叶皮质(IC)损伤对味觉刺激摄取的影响。在正常大鼠中，当糖精的味道是新的而不是熟悉的时候，吗啡会导致糖精摄入量迅速减少。不考虑刺激的新颖性，吗啡对IC损毁大鼠的糖精消耗几乎没有影响。结果从病变引起的(I)奖励比较机制和(Ii)味觉新颖性的破坏的角度进行了讨论。
The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.