Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies.
Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies.
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DOI：
10.1016/j.tibs.2016.01.002
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发表时间：
2016-03
影响因子：
13.8
通讯作者：
Rutter J
中科院分区：
文献类型：
--
作者：
Olson KA;Schell JC;Rutter J
代谢失调是癌症的一个新出现的标志，人们对开发选择性靶向这些异常代谢表型的疗法非常感兴趣。处于线粒体碳水化合物氧化和有氧糖酵解之间的决定点（即，“瓦尔堡效应”），丙酮酸的合成和消耗受到严格控制，并且在癌细胞中经常受到差异调节。本文综述了最近的努力，了解和靶向线粒体丙酮酸代谢，并解决了一些成功，陷阱和代谢治疗的重大挑战。
Dysregulated metabolism is an emerging hallmark of cancer and there is abundant interest in developing therapies to selectively target these aberrant metabolic phenotypes. Sitting at the decision point between mitochondrial carbohydrate oxidation and aerobic glycolysis (i.e., the “Warburg Effect”), the synthesis and consumption of pyruvate is tightly controlled and is often differentially regulated in cancer cells. This review examines recent efforts toward understanding and targeting mitochondrial pyruvate metabolism, and addresses some of the successes, pitfalls and significant challenges of metabolic therapy to date.