Auditory brainstem responses in pervasive developmental disorders.
Auditory brainstem responses in pervasive developmental disorders.
复制标题
广泛性发育障碍中的听觉脑干反应。
作者：
J. Rumsey;A. Grimes;A. Pikus;R. Duara;D. Ismond
几项研究报告称，在自闭症儿童中测量的听觉脑干反应（ABR）的神经传递时间延长，这一发现表明自闭症患者脑干水平的中枢神经系统功能障碍。这项研究测量了 25 名患有广泛性发育障碍 (PDD)（包括自闭症）的儿童和成人以及 25 名年龄和性别匹配的正常对照者的 ABR。对受试者进行听力和神经学方面的仔细评估，并控制伪影以产生高度可靠的测量结果。仅在一名 PDD 受试者和一名正常对照中观察到传输时间延长，而在四名 PDD 受试者中观察到传输时间缩短。大多数 PDD 受试者的 ABR 正常。因此，之前关于自闭症和类自闭症受试者中传播时间延长的显着发生率的报告并未得到重复。讨论了造成这种差异的可能原因。
Several studies have reported prolonged neural transmission times on auditory brainstem responses (ABRs) measured in autistic children, a finding which implicates CNS dysfunction at the level of the brainstem in autistic conditions. This study measured ABRs in 25 children and adults with pervasive developmental disorders (PDDs), including autism, and 25 age- and sex-matched normal controls. Subjects were carefully evaluated audiometrically and neurologically and artifact was controlled to produce highly reliable measures. Prolonged transmission times were seen in only one PDD subject and in one normal control, while shortened transmission times were seen in four PDD subjects. The majority of PDD subjects showed normal ABRs. Previous reports of a significant incidence of prolonged transmission times among autistic and autisticlike subjects, thus, were not replicated. Possible reasons for this discrepancy are discussed.