Adaptation of a conjugal transfer system for the export of pathogenic macromolecules.
Adaptation of a conjugal transfer system for the export of pathogenic macromolecules.
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DOI：
10.1016/0966-842x(96)81513-7
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发表时间：
1996-02
影响因子：
15.9
通讯作者：
S. C. Winans;Drusilla. Burns;P. Christie
中科院分区：
文献类型：
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作者：
S. C. Winans;Drusilla. Burns;P. Christie
自然界提供了无数的例子，说明如何挪用和改造熟悉的蛋白质或蛋白质组，以满足新出现的需求。一个例子是最近发现的两种不相关的病原菌对接合转移系统的适应。细菌接合，即质粒DNA通过细胞与细胞接触的水平转移，存在于许多或大多数原核生物中。最近已经变得明显的是，植物病原体根癌土壤杆菌和人类病原体百日咳博德特氏菌已经独立地选择了一组类似的tra（接合转移系统）基因用于输出巨噬细胞，
N ature provides countless examples of the appropriation and adaptation of familiar proteins or groups of proteins to satisfy newly arising needs. One example is the recently discovered adaptation of a conjugal transfer system by two unrelated pathogenic bacteria. Bacterial conjugation, the horizontal transfer of plasmid DNA by cell-to-cell contact, is found in many or perhaps most prokaryotes. It has recently become apparent that the plant pathogen Agrobacterium tumefaciens and the human pathogen Bordetella pertussis have independently coopted a similar set of tra (conjugal transfer system) genes for the export of macro-