Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain -: art. no. RC209
Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain -: art. no. RC209
复制标题
DOI：
10.1523/jneurosci.22-04-j0001.2002
复制
发表时间：
2002-02-15
影响因子：
5.3
通讯作者：
Zipp, F
中科院分区：
文献类型：
--
作者：
Dörr, J;Bechmann, I;Zipp, F
肿瘤坏死因子-神经生长因子超家族成员介导的细胞凋亡在神经系统和免疫系统的相互作用中起着至关重要的作用。一方面，它参与了大脑的防御机制，免疫豁免权。另一方面，它参与了神经炎症性疾病中神经胶质细胞死亡的诱导。在这里，我们发现与其他已知的死亡配体不同，肿瘤坏死因子相关的凋亡诱导配体(TRAIL)在人脑中没有结构性表达，而在神经元、星形胶质细胞和少突胶质细胞上发现了介导和阻断凋亡的TRAIL受体。因此，大脑不同于其他免疫特权器官，如胎盘，TRAIL受体-TRAIL系统不是大脑免疫特权的一部分。相反，这种死亡受体-配体系统很可能在T细胞介导的中枢神经系统自身免疫性疾病中发挥重要作用，如多发性硬化症。
Apoptosis mediated by members of the tumor necrosis factor (TNF)-nerve growth factor superfamily plays a crucial role in the interaction of the nervous and the immune system. On the one hand, it is involved in the defense mechanisms of the brain, the immune privilege. On the other hand, it is involved in the induction of glial-neuronal cell death in neuroinflammatory diseases. Here, we show that in contrast to the other known death ligands, TNF-related apoptosis-inducing ligand (TRAIL) is not constitutively expressed in the human brain, whereas both apoptosis-mediating and apoptosis-blocking TRAIL receptors are found on neurons, astrocytes, and oligodendrocytes. Thus, the brain differs from other immune-privileged organs, such as the placenta, with the TRAIL receptor-TRAIL system not being part of the immune privilege of the brain. Conversely, this death receptor-ligand system might well play an important role in T cell-mediated autoimmune diseases of the CNS such as multiple sclerosis.