TNFRSF13B in B cell responses to organ transplantation.
TNFRSF13B in B cell responses to organ transplantation.
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DOI：
10.1016/j.humimm.2022.09.006
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发表时间：
2023-01
期刊：
影响因子：
2.7
通讯作者：
Platt, Jeffrey L.
中科院分区：
文献类型：
--
作者：
Cascalho, Marilia;Platt, Jeffrey L.
关键词：
针对器官移植的抗体被认为对移植物的持久功能和存活构成最令人烦恼的障碍，特别是器官异种移植，因此基础和临床研究集中于阐明移植物特异性抗体的特异性和致病性。虽然人们对这些问题了解很多，但对于产生移植物特异性抗体的 B 细胞以及为什么这些抗体似乎会损伤某些移植物而不是其他移植物，人们知之甚少。为了解决这些问题，我们研究了肿瘤坏死因子受体超家族 13B (TNFRSF13B) 的特性，它调节 B 细胞反应的各个方面。然而，极端多态性和蛋白质相互作用的多样性阻碍了对 TNFRSF13B 功能的充分理解。然而，TNFRSF13B 变体被发现对自然和引发的抗体反应和宿主防御产生明显影响，并且 TNFRSF13B 突变被发现影响抗体介导的器官移植排斥的发生倾向。由于 B 细胞反应可能限制异种移植的应用，了解 TNFRSF13B 多样性和 TNFRSF13B 变异如何控制异种移植中的免疫可能会激发新型疗法的开发，从而加速异种移植的临床实施。
Antibodies directed against organ transplants are thought to pose the most vexing hurdle to enduring function and survival of the transplants, particularly organ xenotransplants, and accordingly basic and clinical investigation has focused on elucidating the specificity and pathogenicity of graft-specific antibodies. While much has been learned about these matters, far less is known about the B cells producing graft-specific antibodies and why these antibodies appear to injure some grafts but not others. With the goal of addressing those questions, we have investigated the properties of tumor necrosis factor receptor super family-13B (TNFRSF13B), which regulates various aspects of B cell responses. A full understanding of the functions of TNFRSF13B however is hindered by extreme polymorphism and by diversity of interactions of the protein. Nevertheless, TNFRSF13B variants have been found to exert distinct impact on natural and elicited antibody responses and host defense and mutations of TNFRSF13B have been found to influence the propensity for development of antibody-mediated rejection of organ transplants. Because B cell responses potentially limit application of xenotransplantation, understanding how TNFRSF13B diversity and TNFRSF13B variants govern immunity in xenotransplantation could inspire development of novel therapeutics that could in turn accelerate clinical implementation of xenotransplantation.
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DOI：
10.1111/ajt.13045
发表时间：
2015-03
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
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影响因子：
10.7
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影响因子：
6.2
作者：
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通讯作者：
PLATT, JL
影响因子：
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作者：
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影响因子：
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作者：
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