Sympathetic toggled sinus rate acceleration as a mechanism of sustained sinus tachycardia in chronic orthostatic intolerance syndrome.
Sympathetic toggled sinus rate acceleration as a mechanism of sustained sinus tachycardia in chronic orthostatic intolerance syndrome.
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交感神经窦性心率加速是慢性直立不耐受综合征持续窦性心动过速的机制。
DOI：
10.1016/j.hrthm.2022.08.015
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发表时间：
2022
期刊：
影响因子：
5.5
通讯作者：
Chen,Peng-Sheng
中科院分区：
文献类型：
--
作者：
Hwang,Daerin;Liu,Xiao;Rosenberg,Carine;Lee,Andrew;Borle,Sanjana;Ricafrente,JoselynQ;Wei,Janet;Shufelt,Chrisandra;Chen,LanS;Li,Xiaochun;Goldhaber,JoshuaI;BaireyMerz,CNoel;Chen,Peng-Sheng
背景交感神经活动在维持窦性心率加速中的作用尚不清楚。目的本研究的目的是验证持续（bbb30秒）窦率加速可能与交感神经驱动或交感神经开关机制有关的假设。方法采用膜片监护仪记录24h皮肤交感神经活动（SKNA）和心电图。研究1包括慢性直立性不耐受（OI）组（n = 18）、房颤组（n = 7）和无症状正常对照组（n = 19）。研究2纳入了17名未接受伊伐布雷定、吡哆斯的明或β受体阻滞剂治疗的慢性成骨不全患者。结果虽然研究1中大多数窦率加速是由持续的SKNA驱动的，但一些发作是由SKNA爆发切换的，而没有持续的SKNA升高。18例慢性成骨不全患者中有7例（39%），7例心房颤动患者中有2例（29%），19例正常对照患者中有6例（32%）出现交感窦性心率加速发作（P= 0.847），慢性成骨不全组的发作速度更快，时间更长。在研究2中，总共有11次窦率加速发作，持续bb200秒。在这些发作中，6例（35%）是由SKNA爆发开关的。结论：慢性成骨不全患者、房颤患者和正常人的持续窦率加速（可开启或关闭）与SKNA爆发有关。与其他组相比，成骨不全患者发作频率更高，时间更长。
BackgroundThe role of sympathetic nerve activity to maintain sinus rate acceleration remains unclear.ObjectiveThe purpose of this study was to test the hypothesis that sustained (>30 seconds) sinus rate acceleration can be associated with either a sympathetic driven or a sympathetic toggled mechanism.MethodsWe used a patch monitor to record skin sympathetic nerve activity (SKNA) and electrocardiogram over 24 hours. Study 1 included chronic orthostatic intolerance (OI) (n = 18), atrial fibrillation (n = 7), and asymptomatic normal control (n = 19) groups. Study 2 included 17 participants with chronic OI not treated with ivabradine, pyridostigmine, or β-blockers.ResultsWhile a majority of sinus rate acceleration was driven by persistent SKNA in study 1, some episodes were toggled on and off by SKNA bursts without persistent SKNA elevation. The sympathetic toggled sinus rate acceleration episodes were found in 7 of 18 participants with chronic OI (39%), 2 of 7 participants with atrial fibrillation (29%), and 6 of 19 normal control participants (32%) (P= .847) and were faster and longer in the chronic OI group than in other groups. In study 2, there were a total of 11 episodes of sinus rate acceleration that persisted for >200 seconds. Among these episodes, 6 (35%) were toggled on and off by SKNA bursts.ConclusionSustained sinus rate acceleration (may be toggled on or off) is associated with SKNA bursts in participants with chronic OI, participants with atrial fibrillation, and normal controls. Patients with OI had more frequent and longer episodes than did other groups.
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姿势性心动过速综合征患者存在内在窦房结异常的证据。
DOI：
10.4065/77.3.246
发表时间：
2002
期刊：
Mayo Clinic proceedings. Mayo Clinic
影响因子：
--
作者：
Singer,Wolfgang;Shen,Win-Kuang;Opfer-Gehrking,TonetteL;McPhee,BenjaminR;Hilz,MaxJ;Low,PhillipA
通讯作者：
Low,PhillipA
影响因子：
9.1
作者：
Olshansky, Brian;Cannom, David;Fedorowski, Artur;Stewart, Julian;Gibbons, Christopher;Sutton, Richard;Shen, Win-Kuang;Muldowney, James;Chung, Tae Hwan;Feigofsky, Suzy;Nayak, Hemal;Calkins, Hugh;Benditt, David G.
通讯作者：
Benditt, David G.
影响因子：
37.8
作者：
Goldstein, DS;Holmes, C;Eisenhofer, G
通讯作者：
Eisenhofer, G
特发性体位性直立性心动过速综合征
影响因子：
9.9
作者：
R. Schondorf;P. Low
通讯作者：
P. Low
B-PO04-165 使用动态心电图记录皮肤交感神经活动
影响因子：
5.5
作者：
Xiao Liu;Joselyn Ricafrente;M. Leier;H. Dinh;T. Everett;Peng
通讯作者：
Peng