Hormone replacement therapy and 24-hour blood pressure profile of postmenopausal women
Hormone replacement therapy and 24-hour blood pressure profile of postmenopausal women
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DOI：
10.1016/s0895-7061(00)00284-3
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发表时间：
2000-09-01
影响因子：
3.2
通讯作者：
Phillips, RA
中科院分区：
文献类型：
--
作者：
Butkevich, A;Abraham, C;Phillips, RA
更年期与血压升高和生理性夜间血压下降有关。这些因素可能在绝经后心血管事件风险增加中发挥作用。一些研究表明，经皮雌激素替代治疗可能有助于恢复24小时血压曲线，但缺乏关于口服结合雌激素影响的数据。我们比较了42名未接受激素替代治疗(HRT)的绝经后妇女和20名接受HRT治疗的妇女的24小时动态血压曲线。HRT与勺型比例显著增加相关(未接受HRT的女性中50%，接受HRT的女性中80%，P=.048)。夜间浸泡的增加可能部分解释了HRT对心血管有益的影响。Am J Hyperten 2000；13：1039-1041(C)2000美国高血压杂志。
Menopause is associated with an increase in blood pressure (BP) and a decrease in physiologic nocturnal BP fall. These factors may play a role in the increased risk of cardiovascular events after menopause. Some studies indicate that transdermal estrogen replacement therapy may help restore the 24-h BP profile, but data on the effect of oral conjugated estrogens are lacking. We compared 24-h ambulatory BP profiles of 42 postmenopausal women not receiving hormone replacement therapy (HRT) and 20 women receiving HRT. HRT was associated with a significant increase in the proportion of dippers (50% in women not receiving HRT and 80% in women receiving HRT, P = .048). Increase in nocturnal dipping may account, in part, for the beneficial cardiovascular effects of HRT. Am J Hypertens 2000;13:1039-1041 (C) 2000 American Journal of Hypertension, Ltd.