An assessment of the effect of the genotype on postoperative venous thromboembolism risk in 140,831 surgical patients.
An assessment of the effect of the genotype on postoperative venous thromboembolism risk in 140,831 surgical patients.
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DOI：
10.1016/j.amsu.2021.102938
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Sillesen M
中科院分区：
文献类型：
--
作者：
A Christensen M;Bonde A;Sillesen M
术后静脉血栓栓塞事件（VTE）是术后发病率和死亡率的主要来源。本研究的目的是调查常见的单核苷酸多态性（SNP）是否与外科环境中的静脉血栓栓塞相关。回顾性研究使用英国（UK）生物库的数据，该生物库是一个基因组生物库，包含超过500，000人的医疗保健和基因分型数据。确定了140，831例接受过注册外科手术的患者队列，并将其用于发现全基因组关联研究（GWAS），其余队列（305，349例非手术患者）用作复制队列。主要结果是手术后30天内SNP与VTE之间的关联。全基因组显著性设定为p = 5 × 10−8。在手术（发现）队列中，没有SNP达到全基因组显著性。ABO基因rs505922（p = 3.33 × 10−7）中最高候选SNP的VTE相关性在一般（复制）队列中重复（p = 2.42 × 10−59）。相关性：这项研究没有确定SNP和术后VTE事件之间的关联达到全基因组意义，尽管证明了首选候选人的VTE相关性。·静脉血栓栓塞在手术后很常见。·大型生物库有助于识别常见的遗传风险因素。ABO常见变异可能会增加术后静脉血栓栓塞的风险。基因分型手术患者可能有利于术前风险评估。
Postoperative Venous Thromboembolism Events (VTE) constitute a major source of morbidity and mortality after surgery. The aim of this study was to investigate whether commonly occurring Single Nucleotide Polymorphisms (SNPs) are associated with VTE in the surgical setting. Retrospective study using data from the United Kingdom (UK) biobank, a genome biobank containing healthcare and genotyping data from more than 500.000 individuals. A cohort of 140,831patients with a registered surgical procedure was identified and used for a discovery genome wide association study (GWAS), with the remainder of the cohort (305,349 non-surgical patients) used as a replication cohort. Primary outcome was associations between SNPs and VTE within 30 days after a surgical procedure. Genome wide significance was set at p = 5 × 10−8. In the surgical (discovery) cohort, no SNPs reached genome wide significance. The VTE association of the top candidate SNP in the ABO gene rs505922 (p = 3.33 × 10−7), was replicated in the general (replication) cohort (p = 2.42 × 10−59). and Relevance: This study did not identify associations between SNPs and postoperative VTE events reaching genome-wide significance, although the VTE relevance of top candidates were demonstrated. •Venous thromboembolisms are common after surgery. •Large biobanks help identify common genetic risk factors. •Common variants in ABO may increase the risk of postoperative venous thromboembolisms. •Genotyping surgical patients may benefit preoperative risk assessment.
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影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
10.4
作者：
Nossent, A. Y.;Van Marion, V.;Eikenboom, H. C. J.
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作者：
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DOI：
10.1111/j.1538-7836.2012.04810.x
发表时间：
2012-08
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
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通讯作者：
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影响因子：
9.6
作者：
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通讯作者：
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