A Mouse Model for Ocular Surface Staphylococcus aureus Infection.
A Mouse Model for Ocular Surface Staphylococcus aureus Infection.
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DOI：
10.1002/cpmo.23
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发表时间：
2017-03-02
影响因子：
--
通讯作者：
Wang G
中科院分区：
文献类型：
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作者：
Zhang Z;Abdel-Razek O;Wang G
寻找一种合适的动物模型，准确反映人类对细菌感染的疾病和宿主防御免疫反应，是眼表感染研究的主要挑战。由于遗传背景和靶向缺陷的多样性、相对较低的成本和现成的可用性以及免疫试剂的可用性，几十年来，小鼠被广泛认为是研究眼表感染的理想小动物模型。通过小鼠与细菌菌株的不同组合，建立小鼠感染模型，探索细菌感染与眼表先天免疫的全貌。在正常眼部环境下使用金黄色葡萄球菌感染小鼠模型进行研究，作为一种方便且易于处理的模型系统，似乎可以代表哺乳动物宿主对病原体的反应。
To find an appropriate animal model that accurately reflects the disease and host defenses immune response to bacterial infection in humans is a major challenge in ocular surface infection research. Due to the variety of genetic backgrounds and targeted defects, the relatively low cost and ready availability, and the immunologic reagents available, mice are widely believed to be the ideal small animal model for ocular surface infection research for decades. By using of different combinations of mouse and bacterial strains, murine infection models can be used to explore a complete picture of bacterial infection and innate immunity in ocular surface. Studies using a murine model of S. aureus infection under normal ocular circumstances serve as a convenient and tractable model system that appears to be representative of mammalian host responses to pathogens.