Seven chromanoid norbisabolane derivatives from the marine-alga-endophytic fungus Trichoderma asperellum A-YMD-9-2
Seven chromanoid norbisabolane derivatives from the marine-alga-endophytic fungus Trichoderma asperellum A-YMD-9-2
复制标题
来自海洋藻类内生真菌木霉菌 A-YMD-9-2 的七种苯并二氢吡喃类降红没药烷衍生物
DOI：
10.1016/j.fitote.2019.04.014
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发表时间：
2019-06-01
期刊：
影响因子：
3.4
通讯作者：
Ji, Nai-Yun
中科院分区：
文献类型：
--
作者：
Song, Yin-Ping;Miao, Feng-Ping;Ji, Nai-Yun
An examination of the endophytic fungus Trichoderma aspereliwn A-YMD-9-2 obtained from the marine red alga Gracilaria verrucosa led to the isolation of seven new chromanoid norbisabolane derivatives, trichobisabolins I-L (1-4) and trichaspsides C-E (5-7). Their structures and relative configurations were established on the basis of spectroscopic techniques, mainly including 1D/2D NMR and MS, and the absolute configuration of 1 was assigned by X-ray crystallographic analysis using Cu K alpha radiation. All of these isolates feature a 1,9-epoxy ring system, and 5-7 represent the second occurrence of norbisabolane aminoglycosides. Compounds 1-7 exhibited potent inhibition of several marine phytoplankton species.
